What compounds affect the Peptide hormone metabolism pathway?

124 compounds in the BiohacksAI corpus have documented interactions with genes in the Peptide hormone metabolism pathway (Reactome ID: R-HSA-2980736). These compounds target 15 genes within this pathway.

What genes are in the Peptide hormone metabolism pathway?

The Peptide hormone metabolism pathway involves 15 genes. Key genes include: ACE, ACHE, BCHE, CES1, CMA1, CTSG, DPP4, FFAR1, FFAR4, GPR119.

Peptide hormone metabolism

REACTOME PATHWAY

Reactome: R-HSA-298073615 genes124 compounds

The Peptide hormone metabolism pathway (Reactome ID: R-HSA-2980736) involves 15 genes and is affected by 124 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ACE ACHE BCHE CES1 CMA1 CTSG DPP4 FFAR1 FFAR4 GPR119 INS MME P4HB PLA2G7 TCF7L2

Compounds Affecting Peptide hormone metabolism

#	Compound	Targets Hit	Studies
1	Physostigmine	—	300
2	Physostigmine	—	299
3	Metergoline	—	144
4	Berberine	—	300
5	ethopropazine	—	17
6	Hexachlorophene	—	300
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	caffeic acid	—	300
9	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
10	Quercetin	—	300
11	Aripiprazole	—	298
12	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
13	Reserpine	—	297
14	Masoprocol	—	300
15	Perphenazine	—	297
16	gamma-Linolenic Acid	—	300
17	Linoleic Acid	—	300
18	alpha-Linolenic Acid	—	300
19	Oleic Acid	—	112
20	Myristic Acid	—	300
21	Thiorphan	—	300
22	Dihydroergotamine	—	9
23	Bortezomib	—	300
24	bis(12)-hupyridone [Supplementary Concept]	—	300
25	Methylene Blue	—	200
26	Ranitidine	—	299
27	Chlorhexidine	—	299
28	Ethidium	—	300
29	Nicergoline	—	300
30	Progesterone	—	299
31	Phenylglyoxal	—	300
32	Procainamide	—	297
33	Tilorone	—	300
34	Acetaldehyde	—	300
35	Carbaryl	—	300
36	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
37	Dihydroergotamine	—	299
38	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	—	298
39	Methysergide	—	300
40	Promethazine	—	121
41	Thioridazine	—	35
42	Caffeine	—	299
43	Amisulpride	—	298
44	Astemizole Antihistamine drug now withdrawn from	—	280
45	Hyoscyamine	—	296
46	Dinitrochlorobenzene	—	300
47	Disulfiram	—	297
48	Edaravone	—	298
49	Methoxsalen	—	300
50	pirenperone	—	22

About the Peptide hormone metabolism Pathway

The Peptide hormone metabolism pathway is catalogued in Reactome (ID: R-HSA-2980736) and involves 15 genes. In the BiohacksAI corpus, 124 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ACE, ACHE, BCHE, CES1, CMA1.