Question 1

What compounds affect the Energy dependent regulation of mTOR by LKB1-AMPK pathway?

Accepted Answer

38 compounds in the BiohacksAI corpus have documented interactions with genes in the Energy dependent regulation of mTOR by LKB1-AMPK pathway (Reactome ID: R-HSA-380972). These compounds target 10 genes within this pathway.

Question 2

What genes are in the Energy dependent regulation of mTOR by LKB1-AMPK pathway?

Accepted Answer

The Energy dependent regulation of mTOR by LKB1-AMPK pathway involves 10 genes. Key genes include: MLST8, MTOR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, RPTOR.

#	Compound	Targets Hit	Studies
1	Rotenone	—	300
2	Niclosamide	—	299
3	Ursolic Acid	—	300
4	Adenosine Monophosphate Adenine nucleotide containing	—	300
5	Proguanil	—	299
6	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
7	Berberine	—	300
8	Antimycin	—	300
9	Oleanolic Acid	—	300
10	Metformin	—	1,000
11	Sirolimus	—	300
12	torin 1	—	10
13	Everolimus	—	297
14	Ku 0063794 [Supplementary Concept]	—	7
15	pictilisib	—	25
16	ly294002	—	11
17	Thapsigargin	—	300
18	Wortmannin	—	300
19	alpelisib	—	227
20	amn082	—	29
21	Calcimycin	—	216
22	Idarubicin	—	299
23	Idazoxan	—	300
24	triolimus [Supplementary Concept]	—	33
25	tyrphostin 9	—	2
26	egcg	—	300
27	Camptothecin	—	300
28	Dequalinium	—	136
29	Disulfiram	—	297
30	Emetine	—	298
31	Epinephrine	—	299
32	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
33	Maprotiline	—	299
34	Perphenazine	—	297
35	Quercetin	—	300
36	Kaempferols	—	300
37	Rutin	—	300
38	Crizotinib	—	298

BiohacksAI

Energy dependent regulation of mTOR by LKB1-AMPK

Genes in this Pathway

Compounds Affecting Energy dependent regulation of mTOR by LKB1-AMPK

About the Energy dependent regulation of mTOR by LKB1-AMPK Pathway