What compounds affect the Metabolism of proteins pathway?

845 compounds in the BiohacksAI corpus have documented interactions with genes in the Metabolism of proteins pathway (Reactome ID: R-HSA-392499). These compounds target 273 genes within this pathway.

What genes are in the Metabolism of proteins pathway?

The Metabolism of proteins pathway involves 273 genes. Key genes include: ACE, ACHE, ADAM10, ADAMTS4, ADAMTS5, ADORA2B, ADRA2A, ADRA2C, ADRB2, ADRM1.

Metabolism of proteins

REACTOME PATHWAY

Reactome: R-HSA-392499273 genes845 compounds

The Metabolism of proteins pathway (Reactome ID: R-HSA-392499) involves 273 genes and is affected by 845 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ACE ACHE ADAM10 ADAMTS4 ADAMTS5 ADORA2B ADRA2A ADRA2C ADRB2 ADRM1 ALB ALDH2 ALPG ALPL APH1A APH1B APP AR ARRB1 ARSA ASPH AURKA AURKB BACE1 BAP1 BARD1 BCHE BIRC5 BLM BRCA1+243 more

Compounds Affecting Metabolism of proteins

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Quercetin	—	300
3	vinblastine sulfate	—	81
4	Podophyllotoxin	—	14
5	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
6	Hexachlorophene	—	300
7	Nocodazole Nocodazole is	—	215
8	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
9	Colchicine	—	300
10	Vorinostat	—	299
11	Reserpine	—	297
12	Vincristine	—	299
13	cycloheximide	—	300
14	egcg	—	300
15	Methylene Blue	—	200
16	Demecolcine	—	246
17	Ethidium	—	300
18	Daunorubicin	—	298
19	Resveratrol	—	298
20	Kaempferols	—	300
21	Astemizole Antihistamine drug now withdrawn from	—	280
22	Genistein	—	300
23	chrysin	—	300
24	Niclosamide	—	299
25	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
26	Digoxin	—	299
27	Disulfiram	—	297
28	Azacitidine	—	298
29	Azacitidine	—	300
30	Chlorhexidine	—	299
31	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
32	alpha-Linolenic Acid	—	300
33	Progesterone	—	299
34	Celecoxib	—	295
35	Noscapine	—	300
36	Dinitrochlorobenzene	—	300
37	sp600125	—	117
38	Nisoldipine	—	297
39	Methotrexate	—	289
40	Emetine	—	298
41	Oxyphenbutazone	—	300
42	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
43	rafoxanide	—	172
44	Dactinomycin	—	297
45	Clotrimazole	—	296
46	Dasatinib	—	299
47	Rutin	—	300
48	piceatannol	—	300
49	Maytansine	—	300
50	Spironolactone	—	298

About the Metabolism of proteins Pathway

The Metabolism of proteins pathway is catalogued in Reactome (ID: R-HSA-392499) and involves 273 genes. In the BiohacksAI corpus, 845 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ACE, ACHE, ADAM10, ADAMTS4, ADAMTS5.