What genes are in the Acetylcholine regulates insulin secretion pathway?

The Acetylcholine regulates insulin secretion pathway involves 3 genes. Key genes include: CHRM3, GNA15, PLCB3.

Acetylcholine regulates insulin secretion

Q: What compounds affect the Acetylcholine regulates insulin secretion pathway?

47 compounds in the BiohacksAI corpus have documented interactions with genes in the Acetylcholine regulates insulin secretion pathway (Reactome ID: R-HSA-399997). These compounds target 3 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-3999973 genes47 compounds

The Acetylcholine regulates insulin secretion pathway (Reactome ID: R-HSA-399997) involves 3 genes and is affected by 47 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CHRM3 GNA15 PLCB3

Compounds Affecting Acetylcholine regulates insulin secretion

#	Compound	Targets Hit	Studies
1	Astemizole Antihistamine drug now withdrawn from	—	280
2	Fluspirilene	—	74
3	Hyoscyamine	—	296
4	N-Methylscopolamine	—	299
5	Arecoline	—	299
6	Pilocarpine	—	297
7	Scopolamine	—	298
8	Muscarine	—	299
9	Hyoscyamine	—	296
10	Ipratropium	—	297
11	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
12	Quetiapine Fumarate	—	994
13	hexahydrosiladiphenidol	—	1
14	Strychnine	—	300
15	Tolterodine Tartrate	—	73
16	Fluoxetine	—	1,000
17	Mianserin	—	299
18	Amoxapine	—	259
19	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
20	Butaclamol	—	300
21	Chlorhexidine	—	299
22	Cyclacillin	—	82
23	Cyproheptadine	—	299
24	dilazep	—	300
25	Dimethindene	—	119
26	Fentanyl	—	300
27	Loxapine	—	225
28	Maprotiline	—	299
29	Metergoline	—	144
30	Nefopam Non-narcotic analgesic chemically similar to ORPHENADRINE. Its mechanism of action is unclear. It is used for	—	299
31	Nortriptyline	—	295
32	oxatomide [Supplementary Concept] structure;	—	128
33	Promethazine	—	296
34	protriptyline	—	296
35	Tilorone	—	300
36	Tiotropium Bromide	—	290
37	Valproic Acid	—	296
38	Vemurafenib	—	298
39	Vincamine	—	300
40	Aripiprazole	—	298
41	Bisphenol A-Glycidyl Methacrylate	—	197
42	Calcimycin	—	216
43	Equilin	—	216
44	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	—	297
45	Sphingosine	—	300
46	Cefixime	—	300
47	Emtricitabine	—	292

About the Acetylcholine regulates insulin secretion Pathway

The Acetylcholine regulates insulin secretion pathway is catalogued in Reactome (ID: R-HSA-399997) and involves 3 genes. In the BiohacksAI corpus, 47 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CHRM3, GNA15, PLCB3.