What genes are in the SUMOylation of intracellular receptors pathway?

The SUMOylation of intracellular receptors pathway involves 22 genes. Key genes include: AR, ESR1, HDAC4, NR1H2, NR1H3, NR1H4, NR1I2, NR2C1, NR3C1, NR3C2.

SUMOylation of intracellular receptors

Q: What compounds affect the SUMOylation of intracellular receptors pathway?

567 compounds in the BiohacksAI corpus have documented interactions with genes in the SUMOylation of intracellular receptors pathway (Reactome ID: R-HSA-4090294). These compounds target 22 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-409029422 genes567 compounds

The SUMOylation of intracellular receptors pathway (Reactome ID: R-HSA-4090294) involves 22 genes and is affected by 567 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AR ESR1 HDAC4 NR1H2 NR1H3 NR1H4 NR1I2 NR2C1 NR3C1 NR3C2 NR4A2 NR5A1 NR5A2 PGR PPARA PPARG RARA RORA RXRA SUMO1 THRA VDR

Compounds Affecting SUMOylation of intracellular receptors

#	Compound	Targets Hit	Studies
1	Progesterone	—	299
2	vinblastine sulfate	—	81
3	Ethidium	—	300
4	Daunorubicin	—	298
5	Aldosterone	—	300
6	Triiodothyronine	—	300
7	Dihydrotestosterone	—	300
8	Spironolactone	—	298
9	cycloheximide	—	300
10	Dactinomycin	—	297
11	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
12	Genistein	—	300
13	chrysin	—	300
14	Troglitazone	—	299
15	Azacitidine	—	298
16	Azacitidine	—	300
17	Hexachlorophene	—	300
18	Resveratrol	—	298
19	Clotrimazole	—	296
20	Methylene Blue	—	200
21	Dinitrochlorobenzene	—	300
22	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
23	Emetine	—	298
24	Podophyllotoxin	—	14
25	Retinaldehyde	—	300
26	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
27	Testosterone	—	299
28	Levonorgestrel	—	292
29	Norgestrel	—	300
30	Ethinyl Estradiol	—	300
31	Budesonide	—	1,000
32	Desoxycorticosterone	—	300
33	Disulfiram	—	297
34	Nisoldipine	—	297
35	Rotenone	—	300
36	Loratadine	—	296
37	Kaempferols	—	300
38	Gestrinone	—	221
39	Quercetin	—	300
40	candesartan cilexetil [Supplementary Concept]	—	300
41	Celecoxib	—	295
42	Dasatinib	—	299
43	o-Phthalaldehyde	—	300
44	Vitamin	—	295
45	Vincristine	—	299
46	Simvastatin	—	1,000
47	Thyroxine	—	994
48	Thyroxine	—	300
49	Gemfibrozil	—	297
50	Medroxyprogesterone Acetate	—	299

About the SUMOylation of intracellular receptors Pathway

The SUMOylation of intracellular receptors pathway is catalogued in Reactome (ID: R-HSA-4090294) and involves 22 genes. In the BiohacksAI corpus, 567 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AR, ESR1, HDAC4, NR1H2, NR1H3.