What compounds affect the Interaction between L1 and Ankyrins pathway?

39 compounds in the BiohacksAI corpus have documented interactions with genes in the Interaction between L1 and Ankyrins pathway (Reactome ID: R-HSA-445095). These compounds target 8 genes within this pathway.

What genes are in the Interaction between L1 and Ankyrins pathway?

The Interaction between L1 and Ankyrins pathway involves 8 genes. Key genes include: SCN1A, SCN2A, SCN3A, SCN4A, SCN5A, SCN7A, SCN8A, SCN9A.

Interaction between L1 and Ankyrins

REACTOME PATHWAY

Reactome: R-HSA-4450958 genes39 compounds

The Interaction between L1 and Ankyrins pathway (Reactome ID: R-HSA-445095) involves 8 genes and is affected by 39 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A SCN9A

Compounds Affecting Interaction between L1 and Ankyrins

#	Compound	Targets Hit	Studies
1	Saxitoxin	—	300
2	Veratridine	—	300
3	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
4	Bupivacaine	—	300
5	Dibucaine	—	299
6	Lidocaine	—	299
7	Quinidine	—	298
8	Flunarizine Flunarizine is	—	299
9	Etidocaine	—	300
10	lidoflazine	—	278
11	Mianserin	—	299
12	Chlorpheniramine	—	298
13	Cinnarizine	—	299
14	Cyproheptadine	—	299
15	Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of	—	296
16	dilazep	—	300
17	Hydroxyzine	—	298
18	Lacosamide	—	297
19	Nortriptyline	—	295
20	Phenobarbital	—	297
21	Phentolamine	—	300
22	Promethazine	—	296
23	protriptyline	—	296
24	Reserpine	—	297
25	Aconitine	—	300
26	Lamotrigine	—	296
27	Phenytoin	—	300
28	Riluzole	—	298
29	Duloxetine Hydrochloride	—	993
30	Flecainide	—	297
31	Nebivolol	—	297
32	Propranolol	—	300
33	Ranolazine	—	297
34	Astemizole Antihistamine drug now withdrawn from	—	280
35	Carvedilol	—	296
36	Domperidone	—	299
37	Nisoldipine	—	297
38	Nitrendipine	—	299
39	Ropivacaine	—	299

About the Interaction between L1 and Ankyrins Pathway

The Interaction between L1 and Ankyrins pathway is catalogued in Reactome (ID: R-HSA-445095) and involves 8 genes. In the BiohacksAI corpus, 39 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include SCN1A, SCN2A, SCN3A, SCN4A, SCN5A.