What compounds affect the Diseases of Immune System pathway?

54 compounds in the BiohacksAI corpus have documented interactions with genes in the Diseases of Immune System pathway (Reactome ID: R-HSA-5260271). These compounds target 11 genes within this pathway.

What genes are in the Diseases of Immune System pathway?

The Diseases of Immune System pathway involves 11 genes. Key genes include: BTK, CHUK, HMGB1, IKBKB, IRAK4, NFKB1, NFKB2, NFKBIA, RELA, TLR2.

Diseases of Immune System

REACTOME PATHWAY

Reactome: R-HSA-526027111 genes54 compounds

The Diseases of Immune System pathway (Reactome ID: R-HSA-5260271) involves 11 genes and is affected by 54 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BTK CHUK HMGB1 IKBKB IRAK4 NFKB1 NFKB2 NFKBIA RELA TLR2 TLR3

Compounds Affecting Diseases of Immune System

#	Compound	Targets Hit	Studies
1	chicoric acid	—	117
2	Quercetin	—	300
3	Resveratrol	—	298
4	Bortezomib	—	300
5	Podophyllotoxin	—	14
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	Kaempferols	—	300
8	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
9	Rutin	—	300
10	Withania	—	500
11	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
12	tamarixetin	—	26
13	withaferin	—	300
14	Trifluridine	—	295
15	tyrphostin ag 1478	—	4
16	vinblastine sulfate	—	81
17	Crizotinib	—	298
18	sp600125	—	117
19	Dasatinib	—	299
20	Hydrocortisone	—	299
21	egcg	—	300
22	Cerulenin	—	300
23	Chlorpropamide	—	300
24	daph	—	2
25	Disulfiram	—	297
26	Hexachlorophene	—	300
27	Hydrocortisone	—	298
28	Lovastatin	—	300
29	ly294002	—	11
30	Promethazine	—	121
31	protriptyline	—	296
32	streptonigrin	—	299
33	Sulfaphenazole	—	300
34	Triamcinolone	—	300
35	tyrphostin 1	—	1
36	Voriconazole	—	299
37	Cathelicidins Antimicrobial cationic peptides with	—	300
38	plumbagin [Supplementary Concept]	—	300
39	Ursolic Acid	—	300
40	Oleanolic Acid	—	300
41	pyrrolidine dithiocarbamate	—	275
42	Budesonide	—	1,000
43	Dibucaine	—	299
44	Dimethylphenylpiperazinium Iodide	—	33
45	Edaravone	—	298
46	Fluocinolone Acetonide	—	295
47	Sulfadimethoxine	—	300
48	alsterpaullone	—	12
49	Aurintricarboxylic Acid	—	184
50	Methotrexate	—	289

About the Diseases of Immune System Pathway

The Diseases of Immune System pathway is catalogued in Reactome (ID: R-HSA-5260271) and involves 11 genes. In the BiohacksAI corpus, 54 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BTK, CHUK, HMGB1, IKBKB, IRAK4.