What compounds affect the Programmed Cell Death pathway?

239 compounds in the BiohacksAI corpus have documented interactions with genes in the Programmed Cell Death pathway (Reactome ID: R-HSA-5357801). These compounds target 63 genes within this pathway.

What genes are in the Programmed Cell Death pathway?

The Programmed Cell Death pathway involves 63 genes. Key genes include: ADRM1, AKT3, BAD, BCL2L1, BCL2L11, BMX, CASP1, CASP4, CASP5, CASP9.

Programmed Cell Death

REACTOME PATHWAY

Reactome: R-HSA-535780163 genes239 compounds

The Programmed Cell Death pathway (Reactome ID: R-HSA-5357801) involves 63 genes and is affected by 239 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 AKT3 BAD BCL2L1 BCL2L11 BMX CASP1 CASP4 CASP5 CASP9 CDC37 DAPK1 DAPK2 DAPK3 ELANE FNTA GSDMD HMGB1 HSP90AA1 IL1B KPNB1 LMNA MAPK1 MAPK3 MAPK8 PRKN PSMA1 PSMA2 PSMA3 PSMA4+33 more

Compounds Affecting Programmed Cell Death

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Disulfiram	—	297
4	sp600125	—	117
5	Quercetin	—	300
6	Hexachlorophene	—	300
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	kenpaullone	—	8
9	Masoprocol	—	300
10	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
11	Niclosamide	—	299
12	plumbagin [Supplementary Concept]	—	300
13	Genistein	—	300
14	cycloheximide	—	300
15	Clotrimazole	—	296
16	celastrol	—	300
17	Harmaline	—	300
18	Idarubicin	—	299
19	pd98059	—	7
20	2-Chloroadenosine 2-Chloroadenosine.	—	300
21	Chlorhexidine	—	299
22	withaferin	—	300
23	alsterpaullone	—	12
24	Anisomycin	—	247
25	pictilisib	—	25
26	felbinac	—	31
27	Ethidium	—	300
28	Ethinyl Estradiol	—	300
29	Methylene Blue	—	200
30	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
31	Methotrexate	—	289
32	Axitinib	—	298
33	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
34	Ciclopirox	—	88
35	daph	—	2
36	Dinitrochlorobenzene	—	300
37	Loratadine	—	296
38	Spironolactone	—	298
39	Thioridazine	—	35
40	vinblastine sulfate	—	81
41	chrysin	—	300
42	Benzalkonium Compounds	—	299
43	Carbazilquinone	—	48
44	Digitoxin	—	300
45	Digoxin	—	299
46	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
47	Nisoldipine	—	297
48	Oxyphenbutazone	—	300
49	triolimus [Supplementary Concept]	—	33
50	triflupromazine hydrochloride	—	12

About the Programmed Cell Death Pathway

The Programmed Cell Death pathway is catalogued in Reactome (ID: R-HSA-5357801) and involves 63 genes. In the BiohacksAI corpus, 239 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, AKT3, BAD, BCL2L1, BCL2L11.