Diseases associated with the TLR signaling cascade

Q: What compounds affect the Diseases associated with the TLR signaling cascade pathway?

54 compounds in the BiohacksAI corpus have documented interactions with genes in the Diseases associated with the TLR signaling cascade pathway (Reactome ID: R-HSA-5602358). These compounds target 11 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-560235811 genes54 compounds

The Diseases associated with the TLR signaling cascade pathway (Reactome ID: R-HSA-5602358) involves 11 genes and is affected by 54 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BTK CHUK HMGB1 IKBKB IRAK4 NFKB1 NFKB2 NFKBIA RELA TLR2 TLR3

Compounds Affecting Diseases associated with the TLR signaling cascade

#	Compound	Targets Hit	Studies
1	chicoric acid	—	117
2	Quercetin	—	300
3	Resveratrol	—	298
4	Bortezomib	—	300
5	Podophyllotoxin	—	14
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	Kaempferols	—	300
8	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
9	Rutin	—	300
10	Withania	—	500
11	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
12	tamarixetin	—	26
13	withaferin	—	300
14	Trifluridine	—	295
15	tyrphostin ag 1478	—	4
16	vinblastine sulfate	—	81
17	Crizotinib	—	298
18	sp600125	—	117
19	Dasatinib	—	299
20	Hydrocortisone	—	299
21	egcg	—	300
22	Cerulenin	—	300
23	Chlorpropamide	—	300
24	daph	—	2
25	Disulfiram	—	297
26	Hexachlorophene	—	300
27	Hydrocortisone	—	298
28	Lovastatin	—	300
29	ly294002	—	11
30	Promethazine	—	121
31	protriptyline	—	296
32	streptonigrin	—	299
33	Sulfaphenazole	—	300
34	Triamcinolone	—	300
35	tyrphostin 1	—	1
36	Voriconazole	—	299
37	Cathelicidins Antimicrobial cationic peptides with	—	300
38	plumbagin [Supplementary Concept]	—	300
39	Ursolic Acid	—	300
40	Oleanolic Acid	—	300
41	pyrrolidine dithiocarbamate	—	275
42	Budesonide	—	1,000
43	Dibucaine	—	299
44	Dimethylphenylpiperazinium Iodide	—	33
45	Edaravone	—	298
46	Fluocinolone Acetonide	—	295
47	Sulfadimethoxine	—	300
48	alsterpaullone	—	12
49	Aurintricarboxylic Acid	—	184
50	Methotrexate	—	289

About the Diseases associated with the TLR signaling cascade Pathway

The Diseases associated with the TLR signaling cascade pathway is catalogued in Reactome (ID: R-HSA-5602358) and involves 11 genes. In the BiohacksAI corpus, 54 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BTK, CHUK, HMGB1, IKBKB, IRAK4.