Defective SLC6A2 causes orthostatic intolerance (OI)

Q: What compounds affect the Defective SLC6A2 causes orthostatic intolerance (OI) pathway?

64 compounds in the BiohacksAI corpus have documented interactions with genes in the Defective SLC6A2 causes orthostatic intolerance (OI) pathway (Reactome ID: R-HSA-5619109). These compounds target 1 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-56191091 genes64 compounds

The Defective SLC6A2 causes orthostatic intolerance (OI) pathway (Reactome ID: R-HSA-5619109) involves 1 genes and is affected by 64 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

SLC6A2

Compounds Affecting Defective SLC6A2 causes orthostatic intolerance (OI)

#	Compound	Targets Hit	Studies
1	Duloxetine Hydrochloride	—	993
2	Fluoxetine	—	1,000
3	protriptyline	—	296
4	Venlafaxine Hydrochloride	—	1,000
5	Venlafaxine Hydrochloride	—	122
6	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
7	Sertraline	—	1,000
8	Maprotiline	—	299
9	Mianserin	—	299
10	Cyproheptadine	—	299
11	Nortriptyline	—	295
12	Reboxetine	—	298
13	Viloxazine	—	296
14	Amoxapine	—	259
15	Aripiprazole	—	298
16	Astemizole Antihistamine drug now withdrawn from	—	280
17	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
18	Desogestrel	—	299
19	Ethinyl Estradiol	—	300
20	Loxapine	—	225
21	Metergoline	—	144
22	Milnacipran	—	5
23	Nortriptyline	—	28
24	Ritodrine	—	87
25	Thiethylperazine	—	165
26	Amlodipine	—	1,000
27	Quetiapine Fumarate	—	994
28	Simvastatin	—	1,000
29	3-Iodobenzylguanidine	—	20
30	amn082	—	29
31	Aprindine	—	300
32	Benzydamine	—	298
33	Cabergoline	—	299
34	Carvedilol	—	296
35	Caspofungin	—	299
36	Chlorhexidine	—	299
37	Chlorpheniramine	—	298
38	cinacalcet	—	298
39	Cinnarizine	—	299
40	Crizotinib	—	298
41	Dequalinium	—	136
42	Flunarizine Flunarizine is	—	299
43	Fluspirilene	—	74
44	Gabexate	—	300
45	Guanabenz	—	298
46	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
47	Hexachlorophene	—	300
48	Idarubicin	—	299
49	Labetalol	—	295
50	Leflunomide	—	297

About the Defective SLC6A2 causes orthostatic intolerance (OI) Pathway

The Defective SLC6A2 causes orthostatic intolerance (OI) pathway is catalogued in Reactome (ID: R-HSA-5619109) and involves 1 genes. In the BiohacksAI corpus, 64 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include SLC6A2.