What genes are in the Activation of HOX genes during differentiation pathway?

The Activation of HOX genes during differentiation pathway involves 16 genes. Key genes include: ASH2L, CREBBP, DPY30, EED, EP300, EZH2, HDAC3, JUN, NCOA3, NCOR1.

Activation of HOX genes during differentiation

Q: What compounds affect the Activation of HOX genes during differentiation pathway?

235 compounds in the BiohacksAI corpus have documented interactions with genes in the Activation of HOX genes during differentiation pathway (Reactome ID: R-HSA-5619507). These compounds target 16 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-561950716 genes235 compounds

The Activation of HOX genes during differentiation pathway (Reactome ID: R-HSA-5619507) involves 16 genes and is affected by 235 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ASH2L CREBBP DPY30 EED EP300 EZH2 HDAC3 JUN NCOA3 NCOR1 RARA RARB RARG RBBP5 RXRA WDR5

Compounds Affecting Activation of HOX genes during differentiation

#	Compound	Targets Hit	Studies
1	Gemfibrozil	—	297
2	s adenosylhomocysteine	—	300
3	Progesterone	—	299
4	Calcitriol	—	300
5	Adapalene	—	296
6	Rotenone	—	300
7	Methylene Blue	—	200
8	Colchicine	—	300
9	Dihydrotestosterone	—	300
10	Disulfiram	—	297
11	cycloheximide	—	300
12	Astemizole Antihistamine drug now withdrawn from	—	280
13	Azacitidine	—	298
14	Azacitidine	—	300
15	Celecoxib	—	295
16	Dactinomycin	—	297
17	Ethidium	—	300
18	Promethazine	—	121
19	Budesonide	—	1,000
20	Genistein	—	300
21	Vitamin	—	295
22	Clotrimazole	—	296
23	Desoxycorticosterone	—	300
24	Nisoldipine	—	297
25	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
26	Testosterone	—	299
27	Chlormadinone Acetate	—	300
28	Daunorubicin	—	298
29	Dimethisterone	—	45
30	Ethoxyquin Antioxidant; also	—	180
31	Flutamide	—	298
32	Lithocholic Acid	—	300
33	Lynestrenol	—	299
34	Medroxyprogesterone Acetate	—	299
35	Niclosamide	—	299
36	triflupromazine hydrochloride	—	12
37	Triiodothyronine	—	300
38	Vincristine	—	299
39	Fluoxetine	—	1,000
40	Iodine	—	300
41	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	1,000
42	Taurine	—	300
43	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	293
44	Bortezomib	—	300
45	Cyproheptadine	—	299
46	Ethynodiol Diacetate	—	300
47	Fluvoxamine	—	297
48	iodoform	—	272
49	Lovastatin	—	300
50	Lumefantrine	—	299

About the Activation of HOX genes during differentiation Pathway

The Activation of HOX genes during differentiation pathway is catalogued in Reactome (ID: R-HSA-5619507) and involves 16 genes. In the BiohacksAI corpus, 235 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ASH2L, CREBBP, DPY30, EED, EP300.