What compounds affect the RHO GTPases activate PKNs pathway?

306 compounds in the BiohacksAI corpus have documented interactions with genes in the RHO GTPases activate PKNs pathway (Reactome ID: R-HSA-5625740). These compounds target 10 genes within this pathway.

What genes are in the RHO GTPases activate PKNs pathway?

The RHO GTPases activate PKNs pathway involves 10 genes. Key genes include: AR, KDM1A, KDM4C, PDPK1, PKN1, PKN2, PKN3, RHOC, YWHAB, YWHAG.

RHO GTPases activate PKNs

REACTOME PATHWAY

Reactome: R-HSA-562574010 genes306 compounds

The RHO GTPases activate PKNs pathway (Reactome ID: R-HSA-5625740) involves 10 genes and is affected by 306 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AR KDM1A KDM4C PDPK1 PKN1 PKN2 PKN3 RHOC YWHAB YWHAG

Compounds Affecting RHO GTPases activate PKNs

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	hydroxyfasudil [Supplementary Concept]	—	11
3	Dasatinib	—	299
4	Masoprocol	—	300
5	triolimus [Supplementary Concept]	—	33
6	Atorvastatin	—	1,000
7	alsterpaullone	—	12
8	Dihydrotestosterone	—	300
9	Progesterone	—	299
10	Testosterone	—	299
11	Medroxyprogesterone Acetate	—	299
12	Spironolactone	—	298
13	Flutamide	—	298
14	Levonorgestrel	—	292
15	Norgestrel	—	300
16	Androstenedione	—	300
17	Ethinyl Estradiol	—	300
18	Testosterone Propionate	—	300
19	Prednisolone	—	1,000
20	Corticosterone	—	300
21	Budesonide	—	1,000
22	Lynestrenol	—	299
23	Methyltestosterone	—	300
24	Oxymetholone	—	298
25	Prednisone	—	298
26	Danazol	—	298
27	Estrone	—	300
28	Norethindrone	—	300
29	Ethisterone 17 alpha-Hydroxypregn-4-en-20-yn-3-one.	—	119
30	Ethynodiol Diacetate	—	300
31	Fluoxymesterone	—	278
32	Nandrolone C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less	—	300
33	cycloheximide	—	300
34	Ethidium	—	300
35	Ouabain	—	300
36	Hydrocortisone	—	299
37	Dehydroepiandrosterone	—	300
38	Betamethasone	—	299
39	Chlormadinone Acetate	—	300
40	Dactinomycin	—	297
41	Dehydroepiandrosterone	—	300
42	Fluorometholone	—	299
43	Hydrocortisone	—	298
44	Desoxycorticosterone	—	300
45	Digoxin	—	299
46	Disulfiram	—	297
47	Finasteride	—	296
48	Methylprednisolone	—	299
49	vinblastine sulfate	—	81
50	17-alpha-Hydroxyprogesterone	—	300

About the RHO GTPases activate PKNs Pathway

The RHO GTPases activate PKNs pathway is catalogued in Reactome (ID: R-HSA-5625740) and involves 10 genes. In the BiohacksAI corpus, 306 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AR, KDM1A, KDM4C, PDPK1, PKN1.