What compounds affect the TP53 Regulates Metabolic Genes pathway?

201 compounds in the BiohacksAI corpus have documented interactions with genes in the TP53 Regulates Metabolic Genes pathway (Reactome ID: R-HSA-5628897). These compounds target 21 genes within this pathway.

What genes are in the TP53 Regulates Metabolic Genes pathway?

The TP53 Regulates Metabolic Genes pathway involves 21 genes. Key genes include: AGO2, AKT3, COX1, COX2, G6PD, GLS, GSR, MLST8, MTOR, PRDX1.

TP53 Regulates Metabolic Genes

REACTOME PATHWAY

Reactome: R-HSA-562889721 genes201 compounds

The TP53 Regulates Metabolic Genes pathway (Reactome ID: R-HSA-5628897) involves 21 genes and is affected by 201 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AGO2 AKT3 COX1 COX2 G6PD GLS GSR MLST8 MTOR PRDX1 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RPTOR TP53 YWHAB YWHAG

Compounds Affecting TP53 Regulates Metabolic Genes

#	Compound	Targets Hit	Studies
1	Rotenone	—	300
2	Niclosamide	—	299
3	Antimycin	—	300
4	Ursolic Acid	—	300
5	Adenosine Monophosphate Adenine nucleotide containing	—	300
6	Proguanil	—	299
7	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
8	Berberine	—	300
9	Oleanolic Acid	—	300
10	Metformin	—	1,000
11	Ku 0063794 [Supplementary Concept]	—	7
12	Disulfiram	—	297
13	Quercetin	—	300
14	Idarubicin	—	299
15	tyrphostin 9	—	2
16	Sirolimus	—	300
17	torin 1	—	10
18	Everolimus	—	297
19	Methylene Blue	—	200
20	Camptothecin	—	300
21	Reserpine	—	297
22	Resveratrol	—	298
23	daph	—	2
24	Physostigmine	—	300
25	Idazoxan	—	300
26	Perphenazine	—	297
27	Physostigmine	—	299
28	triolimus [Supplementary Concept]	—	33
29	Doxycycline	—	999
30	alpha-Linolenic Acid	—	300
31	Carmustine	—	297
32	Emetine	—	298
33	Hydroxyurea	—	300
34	Maprotiline	—	299
35	Thapsigargin	—	300
36	Calcimycin	—	216
37	Ethidium	—	300
38	Ethinyl Estradiol	—	300
39	Hexachlorophene	—	300
40	Azacitidine	—	298
41	Azacitidine	—	300
42	Bortezomib	—	300
43	Azathioprine	—	300
44	Cladribine	—	297
45	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
46	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
47	Cytarabine	—	297
48	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
49	Melphalan	—	300
50	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300

About the TP53 Regulates Metabolic Genes Pathway

The TP53 Regulates Metabolic Genes pathway is catalogued in Reactome (ID: R-HSA-5628897) and involves 21 genes. In the BiohacksAI corpus, 201 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AGO2, AKT3, COX1, COX2, G6PD.