What compounds affect the DNA Double Strand Break Response pathway?

295 compounds in the BiohacksAI corpus have documented interactions with genes in the DNA Double Strand Break Response pathway (Reactome ID: R-HSA-5693606). These compounds target 15 genes within this pathway.

What genes are in the DNA Double Strand Break Response pathway?

The DNA Double Strand Break Response pathway involves 15 genes. Key genes include: ABL1, ATM, BAP1, BARD1, BRCA1, CHEK2, EYA2, KDM4A, KDM4B, MAPK8.

DNA Double Strand Break Response

REACTOME PATHWAY

Reactome: R-HSA-569360615 genes295 compounds

The DNA Double Strand Break Response pathway (Reactome ID: R-HSA-5693606) involves 15 genes and is affected by 295 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 ATM BAP1 BARD1 BRCA1 CHEK2 EYA2 KDM4A KDM4B MAPK8 NSD2 PPP5C SUMO1 TP53 UBE2N

Compounds Affecting DNA Double Strand Break Response

#	Compound	Targets Hit	Studies
1	Chlorhexidine	—	299
2	Nocodazole Nocodazole is	—	215
3	Astemizole Antihistamine drug now withdrawn from	—	280
4	Hexachlorophene	—	300
5	Axitinib	—	298
6	Methotrexate	—	289
7	Colchicine	—	300
8	cycloheximide	—	300
9	Melphalan	—	300
10	sp600125	—	117
11	Trifluridine	—	295
12	vinblastine sulfate	—	81
13	Azacitidine	—	298
14	Azacitidine	—	300
15	Ciclopirox	—	88
16	Cytarabine	—	297
17	Demecolcine	—	246
18	Niclosamide	—	299
19	triolimus [Supplementary Concept]	—	33
20	Dasatinib	—	299
21	Methylene Blue	—	200
22	Podophyllotoxin	—	14
23	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
24	Quercetin	—	300
25	Sertraline	—	1,000
26	alsterpaullone	—	12
27	Fluspirilene	—	74
28	kenpaullone	—	8
29	lidoflazine	—	278
30	Perphenazine	—	297
31	Resveratrol	—	298
32	rafoxanide	—	172
33	Calcimycin	—	216
34	Azathioprine	—	300
35	Bortezomib	—	300
36	Crizotinib	—	298
37	Disulfiram	—	297
38	Maprotiline	—	299
39	alpelisib	—	227
40	Clofarabine	—	298
41	Decitabine	—	298
42	Deferasirox	—	298
43	Digitoxin	—	300
44	Digoxin	—	299
45	Emetine	—	298
46	Ethidium	—	300
47	monorden	—	8
48	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
49	pictilisib	—	25
50	Sorafenib	—	300

About the DNA Double Strand Break Response Pathway

The DNA Double Strand Break Response pathway is catalogued in Reactome (ID: R-HSA-5693606) and involves 15 genes. In the BiohacksAI corpus, 295 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ATM, BAP1, BARD1, BRCA1.