What compounds affect the Activation of the pre-replicative complex pathway?

62 compounds in the BiohacksAI corpus have documented interactions with genes in the Activation of the pre-replicative complex pathway (Reactome ID: R-HSA-68962). These compounds target 3 genes within this pathway.

What genes are in the Activation of the pre-replicative complex pathway?

The Activation of the pre-replicative complex pathway involves 3 genes. Key genes include: CDC7, CDK2, GMNN.

Activation of the pre-replicative complex

REACTOME PATHWAY

Reactome: R-HSA-689623 genes62 compounds

The Activation of the pre-replicative complex pathway (Reactome ID: R-HSA-68962) involves 3 genes and is affected by 62 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDC7 CDK2 GMNN

Compounds Affecting Activation of the pre-replicative complex

#	Compound	Targets Hit	Studies
1	kenpaullone	—	8
2	alsterpaullone	—	12
3	sp600125	—	117
4	Disulfiram	—	297
5	Colchicine	—	300
6	Rotenone	—	300
7	2-Methoxyestradiol	—	300
8	Nocodazole Nocodazole is	—	215
9	Astemizole Antihistamine drug now withdrawn from	—	280
10	Metergoline	—	144
11	Podophyllotoxin	—	14
12	triflupromazine hydrochloride	—	12
13	Vorinostat	—	299
14	Calcimycin	—	216
15	Dasatinib	—	299
16	Digitoxin	—	300
17	Doxazosin	—	24
18	Ethinyl Estradiol	—	300
19	Hexachlorophene	—	300
20	Niclosamide	—	299
21	Reserpine	—	297
22	Duloxetine Hydrochloride	—	993
23	Oleic Acid	—	112
24	ag490	—	14
25	Azacitidine	—	298
26	Azacitidine	—	300
27	Calcifediol	—	300
28	Calcitriol	—	300
29	Cholecalciferol Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of	—	299
30	cinacalcet	—	298
31	Clotrimazole	—	296
32	Decitabine	—	298
33	Desogestrel	—	299
34	Dibucaine	—	299
35	Digoxin	—	299
36	Ethylestrenol	—	70
37	Ethylmaleimide	—	300
38	Feprazone	—	63
39	Flunarizine Flunarizine is	—	299
40	Flunarizine Flunarizine is	—	14
41	Fluspirilene	—	74
42	gedunin	—	54
43	Idazoxan	—	300
44	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
45	Loratadine	—	296
46	Methyldopa	—	297
47	Nisoldipine	—	297
48	Masoprocol	—	300
49	Ouabain	—	300
50	paxilline	—	42

About the Activation of the pre-replicative complex Pathway

The Activation of the pre-replicative complex pathway is catalogued in Reactome (ID: R-HSA-68962) and involves 3 genes. In the BiohacksAI corpus, 62 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDC7, CDK2, GMNN.