What compounds affect the G1/S DNA Damage Checkpoints pathway?

199 compounds in the BiohacksAI corpus have documented interactions with genes in the G1/S DNA Damage Checkpoints pathway (Reactome ID: R-HSA-69615). These compounds target 51 genes within this pathway.

What genes are in the G1/S DNA Damage Checkpoints pathway?

The G1/S DNA Damage Checkpoints pathway involves 51 genes. Key genes include: ADRM1, ATM, CCNA1, CCNE2, CDC25A, CDK2, CHEK1, CHEK2, CSNK1A1, CSNK1E.

G1/S DNA Damage Checkpoints

REACTOME PATHWAY

Reactome: R-HSA-6961551 genes199 compounds

The G1/S DNA Damage Checkpoints pathway (Reactome ID: R-HSA-69615) involves 51 genes and is affected by 199 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 ATM CCNA1 CCNE2 CDC25A CDK2 CHEK1 CHEK2 CSNK1A1 CSNK1E CUL1 GSK3B MAPK11 MAPK14 MDM2 MDM4 NEK11 PLK3 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5+21 more

Compounds Affecting G1/S DNA Damage Checkpoints

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	sp600125	—	117
4	kenpaullone	—	8
5	alsterpaullone	—	12
6	Methylene Blue	—	200
7	Quercetin	—	300
8	Dasatinib	—	299
9	Anisomycin	—	247
10	Sorafenib	—	300
11	egcg	—	300
12	Hexachlorophene	—	300
13	Azacitidine	—	298
14	Azacitidine	—	300
15	Cladribine	—	297
16	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
17	Cytarabine	—	297
18	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
19	Melphalan	—	300
20	Niclosamide	—	299
21	Methotrexate	—	289
22	Trifluridine	—	295
23	ninhydrin	—	300
24	Ciclopirox	—	88
25	cycloheximide	—	300
26	Dinitrochlorobenzene	—	300
27	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
28	Vorinostat	—	299
29	Spironolactone	—	298
30	Thioridazine	—	35
31	vinblastine sulfate	—	81
32	chrysin	—	300
33	Digoxin	—	299
34	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
35	Nisoldipine	—	297
36	Nocodazole Nocodazole is	—	215
37	Oxyphenbutazone	—	300
38	rafoxanide	—	172
39	Sertraline	—	1,000
40	Astemizole Antihistamine drug now withdrawn from	—	280
41	Chlorhexidine	—	299
42	Colchicine	—	300
43	Demecolcine	—	246
44	tyrphostin 9	—	2
45	withaferin	—	300
46	streptonigrin	—	299
47	Ursolic Acid	—	300
48	Lovastatin	—	300
49	Afatinib	—	297
50	Disulfiram	—	297

About the G1/S DNA Damage Checkpoints Pathway

The G1/S DNA Damage Checkpoints pathway is catalogued in Reactome (ID: R-HSA-69615) and involves 51 genes. In the BiohacksAI corpus, 199 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, ATM, CCNA1, CCNE2, CDC25A.