What compounds affect the RNA Polymerase II Transcription pathway?

808 compounds in the BiohacksAI corpus have documented interactions with genes in the RNA Polymerase II Transcription pathway (Reactome ID: R-HSA-73857). These compounds target 259 genes within this pathway.

What genes are in the RNA Polymerase II Transcription pathway?

The RNA Polymerase II Transcription pathway involves 259 genes. Key genes include: ABL1, ADRM1, AGO2, AKT3, AR, ARNT, ASH2L, ATM, AURKA, AURKB.

RNA Polymerase II Transcription

REACTOME PATHWAY

Reactome: R-HSA-73857259 genes808 compounds

The RNA Polymerase II Transcription pathway (Reactome ID: R-HSA-73857) involves 259 genes and is affected by 808 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 ADRM1 AGO2 AKT3 AR ARNT ASH2L ATM AURKA AURKB BARD1 BCL2L11 BIRC5 BLK BLM BRCA1 BRD2 CAMK2B CAMK2D CARM1 CASP1 CASP2 CBFB CCNA1 CCNB1 CCNC CCNE2 CCNT2 CDC7 CDK1+229 more

Compounds Affecting RNA Polymerase II Transcription

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Quercetin	—	300
3	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
4	Daunorubicin	—	298
5	chrysin	—	300
6	Dasatinib	—	299
7	sp600125	—	117
8	Disulfiram	—	297
9	Hexachlorophene	—	300
10	Sorafenib	—	300
11	Progesterone	—	299
12	Ethidium	—	300
13	Rotenone	—	300
14	Niclosamide	—	299
15	kenpaullone	—	8
16	Ursolic Acid	—	300
17	alsterpaullone	—	12
18	vinblastine sulfate	—	81
19	Resveratrol	—	298
20	Celecoxib	—	295
21	Genistein	—	300
22	Kaempferols	—	300
23	Methylene Blue	—	200
24	Podophyllotoxin	—	14
25	Nocodazole Nocodazole is	—	215
26	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
27	cycloheximide	—	300
28	Reserpine	—	297
29	Dactinomycin	—	297
30	Azacitidine	—	298
31	Azacitidine	—	300
32	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
33	Nisoldipine	—	297
34	Colchicine	—	300
35	egcg	—	300
36	Axitinib	—	298
37	Astemizole Antihistamine drug now withdrawn from	—	280
38	Vorinostat	—	299
39	pictilisib	—	25
40	Ethinyl Estradiol	—	300
41	Chlorhexidine	—	299
42	Clotrimazole	—	296
43	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
44	Camptothecin	—	300
45	Emetine	—	298
46	Crizotinib	—	298
47	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
48	Spironolactone	—	298
49	Dinitrochlorobenzene	—	300
50	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300

About the RNA Polymerase II Transcription Pathway

The RNA Polymerase II Transcription pathway is catalogued in Reactome (ID: R-HSA-73857) and involves 259 genes. In the BiohacksAI corpus, 808 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ADRM1, AGO2, AKT3, AR.