What compounds affect the Signaling by Insulin receptor pathway?

71 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by Insulin receptor pathway (Reactome ID: R-HSA-74752). These compounds target 22 genes within this pathway.

What genes are in the Signaling by Insulin receptor pathway?

The Signaling by Insulin receptor pathway involves 22 genes. Key genes include: ATP6V1B2, FGF22, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, GRB2, IDE, INS.

Signaling by Insulin receptor

REACTOME PATHWAY

Reactome: R-HSA-7475222 genes71 compounds

The Signaling by Insulin receptor pathway (Reactome ID: R-HSA-74752) involves 22 genes and is affected by 71 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATP6V1B2 FGF22 FGFR1 FGFR2 FGFR3 FGFR4 FLT3 GRB2 IDE INS INSR MAPK1 MAPK3 PDE3B PDPK1 PIK3C3 PIK3CB PIK3R1 PIK3R2 PTPN1 PTPRF TLR9

Compounds Affecting Signaling by Insulin receptor

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	sp600125	—	117
3	pictilisib	—	25
4	alsterpaullone	—	12
5	kenpaullone	—	8
6	Axitinib	—	298
7	Crizotinib	—	298
8	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
9	Wortmannin	—	300
10	ly294002	—	11
11	Sirolimus	—	300
12	Dasatinib	—	299
13	plumbagin [Supplementary Concept]	—	300
14	pd98059	—	7
15	tyrphostin ag 1478	—	4
16	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
17	Lithocholic Acid	—	300
18	trametinib	—	296
19	withaferin	—	300
20	Ursolic Acid	—	300
21	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
22	Quercetin	—	300
23	alpelisib	—	227
24	torin 1	—	10
25	Clotrimazole	—	296
26	fisetin	—	78
27	Progesterone	—	299
28	2-Chloroadenosine 2-Chloroadenosine.	—	300
29	Benzalkonium Compounds	—	299
30	Calcimycin	—	216
31	daph	—	2
32	Diphenhydramine	—	14
33	ha1004	—	4
34	Loratadine	—	296
35	trequinsin hydrochloride	—	1
36	Oleanolic Acid	—	300
37	celastrol	—	300
38	Okadaic Acid	—	300
39	caffeic acid	—	300
40	Chlorogenic Acid	—	300
41	Methylene Blue	—	200
42	Oleic Acid	—	112
43	Mepentol [Supplementary Concept]	—	184
44	Evans Blue	—	300
45	Palmitic Acid	—	300
46	prunetin	—	35
47	Suramin	—	300
48	vanadates	—	284
49	Afatinib	—	297
50	tyrphostin ag 1295	—	1

About the Signaling by Insulin receptor Pathway

The Signaling by Insulin receptor pathway is catalogued in Reactome (ID: R-HSA-74752) and involves 22 genes. In the BiohacksAI corpus, 71 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATP6V1B2, FGF22, FGFR1, FGFR2, FGFR3.