Advanced glycosylation endproduct receptor signaling

Q: What compounds affect the Advanced glycosylation endproduct receptor signaling pathway?

52 compounds in the BiohacksAI corpus have documented interactions with genes in the Advanced glycosylation endproduct receptor signaling pathway (Reactome ID: R-HSA-879415). These compounds target 5 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-8794155 genes52 compounds

The Advanced glycosylation endproduct receptor signaling pathway (Reactome ID: R-HSA-879415) involves 5 genes and is affected by 52 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

APP HMGB1 MAPK1 MAPK3 S100B

Compounds Affecting Advanced glycosylation endproduct receptor signaling

#	Compound	Targets Hit	Studies
1	plumbagin [Supplementary Concept]	—	300
2	pd98059	—	7
3	alsterpaullone	—	12
4	kenpaullone	—	8
5	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
6	Sorafenib	—	300
7	trametinib	—	296
8	withaferin	—	300
9	Resveratrol	—	298
10	Quercetin	—	300
11	egcg	—	300
12	Hesperidin	—	300
13	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
14	Kaempferols	—	300
15	Methylene Blue	—	200
16	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
17	(N-methyl-C-11)-2-(4-methylamino-phenyl)-6-hydroxybenzothiazole [Supplementary Concept] neutral analog of amyloid-binding thioflavin-T (BTA) that crosses	—	300
18	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
19	caffeic acid	—	300
20	Vitamin	—	295
21	2-Methoxyestradiol	—	300
22	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300
23	Cladribine	—	297
24	Digitoxin	—	300
25	Digoxin	—	299
26	Disulfiram	—	297
27	Edetic Acid	—	24
28	Catechin	—	300
29	Vanillic Acid	—	300
30	Ouabain	—	300
31	Podophyllotoxin	—	14
32	Quinic Acid	—	218
33	Retinaldehyde	—	300
34	streptonigrin	—	299
35	Trifluridine	—	295
36	tyrphostin ag 1478	—	4
37	Clotrimazole	—	296
38	sp600125	—	117
39	fisetin	—	78
40	Progesterone	—	299
41	2-Chloroadenosine 2-Chloroadenosine.	—	300
42	Benzalkonium Compounds	—	299
43	Calcimycin	—	216
44	daph	—	2
45	Diphenhydramine	—	14
46	ha1004	—	4
47	Lithocholic Acid	—	300
48	Loratadine	—	296
49	trequinsin hydrochloride	—	1
50	Methotrexate	—	289

About the Advanced glycosylation endproduct receptor signaling Pathway

The Advanced glycosylation endproduct receptor signaling pathway is catalogued in Reactome (ID: R-HSA-879415) and involves 5 genes. In the BiohacksAI corpus, 52 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include APP, HMGB1, MAPK1, MAPK3, S100B.