What genes are in the Gastrin-CREB signalling pathway via PKC and MAPK pathway?

The Gastrin-CREB signalling pathway via PKC and MAPK pathway involves 10 genes. Key genes include: CCKBR, CREB1, EGFR, GRB2, MAPK1, MAPK3, MAPK7, RPS6KA1, RPS6KA2, RPS6KA3.

Gastrin-CREB signalling pathway via PKC and MAPK

Q: What compounds affect the Gastrin-CREB signalling pathway via PKC and MAPK pathway?

77 compounds in the BiohacksAI corpus have documented interactions with genes in the Gastrin-CREB signalling pathway via PKC and MAPK pathway (Reactome ID: R-HSA-881907). These compounds target 10 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-88190710 genes77 compounds

The Gastrin-CREB signalling pathway via PKC and MAPK pathway (Reactome ID: R-HSA-881907) involves 10 genes and is affected by 77 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CCKBR CREB1 EGFR GRB2 MAPK1 MAPK3 MAPK7 RPS6KA1 RPS6KA2 RPS6KA3

Compounds Affecting Gastrin-CREB signalling pathway via PKC and MAPK

#	Compound	Targets Hit	Studies
1	fisetin	—	78
2	sp600125	—	117
3	Sorafenib	—	300
4	Dactinomycin	—	297
5	trequinsin hydrochloride	—	1
6	Dasatinib	—	299
7	plumbagin [Supplementary Concept]	—	300
8	pd98059	—	7
9	tyrphostin ag 1478	—	4
10	alsterpaullone	—	12
11	kenpaullone	—	8
12	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
13	trametinib	—	296
14	withaferin	—	300
15	hydroxyfasudil [Supplementary Concept]	—	11
16	cycloheximide	—	300
17	Disulfiram	—	297
18	Azacitidine	—	298
19	Azacitidine	—	300
20	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
21	Levalbuterol	—	1,000
22	Adenosine Monophosphate Adenine nucleotide containing	—	300
23	Levalbuterol	—	297
24	Bortezomib	—	300
25	Clofarabine	—	298
26	Danazol	—	298
27	Emetine	—	298
28	Ethidium	—	300
29	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
30	Sulbactam	—	299
31	chrysin	—	300
32	Genistein	—	300
33	Quercetin	—	300
34	Testosterone	—	299
35	Ciclopirox	—	88
36	Cladribine	—	297
37	Clenbuterol	—	300
38	Corticosterone	—	300
39	Daunorubicin	—	298
40	Dinoprostone	—	296
41	Epinephrine	—	299
42	Ethinyl Estradiol	—	300
43	Imatinib Mesylate	—	300
44	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
45	Nisoldipine	—	297
46	Nocodazole Nocodazole is	—	215
47	Masoprocol	—	300
48	Norepinephrine Precursor of epinephrine that is secreted by	—	298
49	o-Phthalaldehyde	—	300
50	Oxyphenbutazone	—	300

About the Gastrin-CREB signalling pathway via PKC and MAPK Pathway

The Gastrin-CREB signalling pathway via PKC and MAPK pathway is catalogued in Reactome (ID: R-HSA-881907) and involves 10 genes. In the BiohacksAI corpus, 77 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCKBR, CREB1, EGFR, GRB2, MAPK1.