What compounds affect the Metabolism of steroids pathway?

329 compounds in the BiohacksAI corpus have documented interactions with genes in the Metabolism of steroids pathway (Reactome ID: R-HSA-8957322). These compounds target 42 genes within this pathway.

What genes are in the Metabolism of steroids pathway?

The Metabolism of steroids pathway involves 42 genes. Key genes include: ABCB11, ABCC3, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALB, CARM1, CREBBP, CYP11B1.

Metabolism of steroids

REACTOME PATHWAY

Reactome: R-HSA-895732242 genes329 compounds

The Metabolism of steroids pathway (Reactome ID: R-HSA-8957322) involves 42 genes and is affected by 329 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCB11 ABCC3 AKR1C1 AKR1C2 AKR1C3 AKR1C4 ALB CARM1 CREBBP CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP24A1 CYP46A1 CYP51A1 CYP8B1 FASN FDPS GC HMGCR HSD11B1 HSD17B1 HSD17B3 KPNB1 NCOA1 NR1H4 OSBP PPARA RAN+12 more

Compounds Affecting Metabolism of steroids

#	Compound	Targets Hit	Studies
1	Clotrimazole	—	296
2	Miconazole	—	298
3	Atorvastatin	—	1,000
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Simvastatin	—	1,000
6	Arachidonic Acid	—	245
7	Genistein	—	300
8	Progesterone	—	299
9	Taurocholic Acid	—	300
10	Olmesartan Medoxomil	—	300
11	chrysin	—	300
12	Testosterone	—	299
13	Ethidium	—	300
14	Reserpine	—	297
15	Dactinomycin	—	297
16	Dihydrotestosterone	—	300
17	Rotenone	—	300
18	Troglitazone	—	299
19	candesartan cilexetil [Supplementary Concept]	—	300
20	Calcitriol	—	300
21	Methotrexate	—	289
22	Ritonavir	—	298
23	Mometasone Furoate	—	292
24	Thyroxine	—	994
25	Taurochenodeoxycholic Acid	—	300
26	Thyroxine	—	300
27	Gemfibrozil	—	297
28	Rifamycins	—	300
29	Rifamycins	—	300
30	Econazole	—	299
31	Letrozole	—	298
32	Fadrozole	—	300
33	Androstenedione	—	300
34	Methylene Blue	—	200
35	cycloheximide	—	300
36	Lovastatin	—	300
37	Disulfiram	—	297
38	Hexachlorophene	—	300
39	Azacitidine	—	298
40	Azacitidine	—	300
41	Chlorhexidine	—	299
42	Daunorubicin	—	298
43	Digoxin	—	299
44	Dinitrochlorobenzene	—	300
45	Emetine	—	298
46	Nisoldipine	—	297
47	Estrone	—	300
48	Idazoxan	—	300
49	Retinaldehyde	—	300
50	vinblastine sulfate	—	81

About the Metabolism of steroids Pathway

The Metabolism of steroids pathway is catalogued in Reactome (ID: R-HSA-8957322) and involves 42 genes. In the BiohacksAI corpus, 329 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCB11, ABCC3, AKR1C1, AKR1C2, AKR1C3.