What compounds affect the Transcriptional Regulation by MECP2 pathway?

262 compounds in the BiohacksAI corpus have documented interactions with genes in the Transcriptional Regulation by MECP2 pathway (Reactome ID: R-HSA-8986944). These compounds target 26 genes within this pathway.

What genes are in the Transcriptional Regulation by MECP2 pathway?

The Transcriptional Regulation by MECP2 pathway involves 26 genes. Key genes include: AGO2, AURKB, CAMK2B, CAMK2D, CREB1, FKBP5, GAMT, GRIA2, GRIN2A, GRIN2B.

Transcriptional Regulation by MECP2

REACTOME PATHWAY

Reactome: R-HSA-898694426 genes262 compounds

The Transcriptional Regulation by MECP2 pathway (Reactome ID: R-HSA-8986944) involves 26 genes and is affected by 262 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AGO2 AURKB CAMK2B CAMK2D CREB1 FKBP5 GAMT GRIA2 GRIN2A GRIN2B HDAC1 HDAC2 HDAC3 HIPK2 HTT IRAK1 MET NCOR1 NCOR2 OPRK1 OPRM1 PPARG PRKACA PTPN1 SGK1 SLC2A3

Compounds Affecting Transcriptional Regulation by MECP2

#	Compound	Targets Hit	Studies
1	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
2	Quercetin	—	300
3	Daunorubicin	—	298
4	sp600125	—	117
5	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
6	Ethidium	—	300
7	pictilisib	—	25
8	scriptaid	—	53
9	Sorafenib	—	300
10	Vorinostat	—	299
11	Resveratrol	—	298
12	Dasatinib	—	299
13	Levorphanol	—	297
14	Celecoxib	—	295
15	Bortezomib	—	300
16	Crizotinib	—	298
17	Ursolic Acid	—	300
18	chrysin	—	300
19	Disulfiram	—	297
20	Dactinomycin	—	297
21	Fluspirilene	—	74
22	Ibogaine	—	300
23	alsterpaullone	—	12
24	Afatinib	—	297
25	Axitinib	—	298
26	Glutamic Acid	—	297
27	Glutamic Acid	—	300
28	Valproic Acid	—	296
29	Butyric Acid	—	300
30	Camptothecin	—	300
31	Methylene Blue	—	200
32	Thyroxine	—	994
33	Thyroxine	—	300
34	Genistein	—	300
35	Triiodothyronine	—	300
36	Kaempferols	—	300
37	Mepentol [Supplementary Concept]	—	184
38	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
39	o-Phthalaldehyde	—	300
40	trequinsin hydrochloride	—	1
41	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
42	Oleic Acid	—	112
43	Vitamin	—	295
44	Biotin	—	297
45	cycloheximide	—	300
46	Hexachlorophene	—	300
47	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
48	Nocodazole Nocodazole is	—	215
49	Sulbactam	—	299
50	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300

About the Transcriptional Regulation by MECP2 Pathway

The Transcriptional Regulation by MECP2 pathway is catalogued in Reactome (ID: R-HSA-8986944) and involves 26 genes. In the BiohacksAI corpus, 262 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AGO2, AURKB, CAMK2B, CAMK2D, CREB1.