Biosynthesis of specialized proresolving mediators (SPMs)

Q: What compounds affect the Biosynthesis of specialized proresolving mediators (SPMs) pathway?

596 compounds in the BiohacksAI corpus have documented interactions with genes in the Biosynthesis of specialized proresolving mediators (SPMs) pathway (Reactome ID: R-HSA-9018678). These compounds target 15 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-901867815 genes596 compounds

The Biosynthesis of specialized proresolving mediators (SPMs) pathway (Reactome ID: R-HSA-9018678) involves 15 genes and is affected by 596 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ALOX12 ALOX15 ALOX5 CYP1A1 CYP1A2 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP3A4 EPHX2 GPX4 HPGD LTA4H PTGS2

Compounds Affecting Biosynthesis of specialized proresolving mediators (SPMs)

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
3	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
4	Kaempferols	—	300
5	cbd	—	298
6	cannabidiol	—	296
7	Hexachlorophene	—	300
8	Masoprocol	—	300
9	Celecoxib	—	295
10	Ethoxyquin Antioxidant; also	—	180
11	Ethidium	—	300
12	Disulfiram	—	297
13	Chlorhexidine	—	299
14	Piribedil	—	300
15	Clotrimazole	—	296
16	Sulindac	—	297
17	Phenelzine	—	297
18	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	1,000
19	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	293
20	amlexanox	—	96
21	ethopropazine hydrochloride	—	2
22	Iodoacetamide	—	300
23	Linoleic Acid	—	300
24	pd98059	—	7
25	Procarbazine	—	299
26	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
27	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
28	Pseudoephedrine	—	298
29	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
30	Hesperidin	—	300
31	fisetin	—	78
32	Methoxsalen	—	300
33	Amoxapine	—	259
34	Danazol	—	298
35	Tolazamide	—	169
36	Piperonyl Butoxide	—	300
37	Methylene Blue	—	200
38	Melphalan	—	300
39	Vitamin K 3	—	300
40	Miconazole	—	298
41	oxatomide [Supplementary Concept] structure;	—	128
42	Phenelzine	—	2
43	Reserpine	—	297
44	Melatonin	—	297
45	Flutamide	—	298
46	Fluvoxamine	—	297
47	Nisoldipine	—	297
48	Phenylthiourea Phenylthiourea is	—	300
49	Bufexamac	—	137
50	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300

About the Biosynthesis of specialized proresolving mediators (SPMs) Pathway

The Biosynthesis of specialized proresolving mediators (SPMs) pathway is catalogued in Reactome (ID: R-HSA-9018678) and involves 15 genes. In the BiohacksAI corpus, 596 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2.