What compounds affect the Interleukin-1 signaling pathway?

245 compounds in the BiohacksAI corpus have documented interactions with genes in the Interleukin-1 signaling pathway (Reactome ID: R-HSA-9020702). These compounds target 56 genes within this pathway.

What genes are in the Interleukin-1 signaling pathway?

The Interleukin-1 signaling pathway involves 56 genes. Key genes include: ADRM1, APP, CHUK, CUL1, HMGB1, IKBKB, IL1B, IRAK1, IRAK3, IRAK4.

Interleukin-1 signaling

REACTOME PATHWAY

Reactome: R-HSA-902070256 genes245 compounds

The Interleukin-1 signaling pathway (Reactome ID: R-HSA-9020702) involves 56 genes and is affected by 245 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 APP CHUK CUL1 HMGB1 IKBKB IL1B IRAK1 IRAK3 IRAK4 MAP2K1 MAP2K4 MAP3K3 MAP3K7 NFKB1 NFKB2 NFKBIA NOD1 NOD2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4+26 more

Compounds Affecting Interleukin-1 signaling

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
4	Disulfiram	—	297
5	Quercetin	—	300
6	Resveratrol	—	298
7	Crizotinib	—	298
8	Axitinib	—	298
9	Digitoxin	—	300
10	Digoxin	—	299
11	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
12	Trifluridine	—	295
13	cycloheximide	—	300
14	Oxyphenbutazone	—	300
15	sp600125	—	117
16	Dasatinib	—	299
17	withaferin	—	300
18	Kaempferols	—	300
19	chicoric acid	—	117
20	Sorafenib	—	300
21	Hexachlorophene	—	300
22	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
23	ninhydrin	—	300
24	Camptothecin	—	300
25	Genistein	—	300
26	Harmaline	—	300
27	Astemizole Antihistamine drug now withdrawn from	—	280
28	Chlorhexidine	—	299
29	alsterpaullone	—	12
30	Anisomycin	—	247
31	streptonigrin	—	299
32	Podophyllotoxin	—	14
33	egcg	—	300
34	Rutin	—	300
35	Withania	—	500
36	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
37	tamarixetin	—	26
38	Ouabain	—	300
39	Vemurafenib	—	298
40	Ethidium	—	300
41	Methylene Blue	—	200
42	Cladribine	—	297
43	Niclosamide	—	299
44	Methotrexate	—	289
45	plumbagin [Supplementary Concept]	—	300
46	daph	—	2
47	Dinitrochlorobenzene	—	300
48	Spironolactone	—	298
49	Thioridazine	—	35
50	vinblastine sulfate	—	81

About the Interleukin-1 signaling Pathway

The Interleukin-1 signaling pathway is catalogued in Reactome (ID: R-HSA-9020702) and involves 56 genes. In the BiohacksAI corpus, 245 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, APP, CHUK, CUL1, HMGB1.