Question 1

What compounds affect the Interleukin receptor SHC signaling pathway?

Accepted Answer

32 compounds in the BiohacksAI corpus have documented interactions with genes in the Interleukin receptor SHC signaling pathway (Reactome ID: R-HSA-912526). These compounds target 11 genes within this pathway.

Question 2

What genes are in the Interleukin receptor SHC signaling pathway?

Accepted Answer

The Interleukin receptor SHC signaling pathway involves 11 genes. Key genes include: GRB2, IL3, INPPL1, JAK2, JAK3, PIK3CB, PIK3CD, PIK3R1, PIK3R2, PIK3R3.

#	Compound	Targets Hit	Studies
1	Sirolimus	—	300
2	pictilisib	—	25
3	ly294002	—	11
4	Wortmannin	—	300
5	alpelisib	—	227
6	torin 1	—	10
7	Crizotinib	—	298
8	Sorafenib	—	300
9	Azauridine	—	300
10	Cladribine	—	297
11	Dasatinib	—	299
12	Methylene Blue	—	200
13	2-Methoxyestradiol	—	300
14	Astemizole Antihistamine drug now withdrawn from	—	280
15	Azathioprine	—	300
16	Calcitriol	—	300
17	Camptothecin	—	300
18	Cytarabine	—	297
19	dihydrorotenone	—	13
20	Podophyllotoxin	—	14
21	streptonigrin	—	299
22	Trifluridine	—	295
23	Tripterygium	—	300
24	Quercetin	—	300
25	Ku 0063794 [Supplementary Concept]	—	7
26	Resveratrol	—	298
27	Methotrexate	—	289
28	sp600125	—	117
29	Axitinib	—	298
30	celastrol	—	300
31	Afatinib	—	297
32	Dactinomycin	—	297

BiohacksAI

Interleukin receptor SHC signaling

Genes in this Pathway

Compounds Affecting Interleukin receptor SHC signaling

About the Interleukin receptor SHC signaling Pathway