What compounds affect the TRAF6 mediated NF-kB activation pathway?

64 compounds in the BiohacksAI corpus have documented interactions with genes in the TRAF6 mediated NF-kB activation pathway (Reactome ID: R-HSA-933542). These compounds target 10 genes within this pathway.

What genes are in the TRAF6 mediated NF-kB activation pathway?

The TRAF6 mediated NF-kB activation pathway involves 10 genes. Key genes include: APP, CHUK, HMGB1, IKBKB, MAP3K1, NFKB1, NFKB2, NFKBIA, RELA, S100B.

TRAF6 mediated NF-kB activation

REACTOME PATHWAY

Reactome: R-HSA-93354210 genes64 compounds

The TRAF6 mediated NF-kB activation pathway (Reactome ID: R-HSA-933542) involves 10 genes and is affected by 64 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

APP CHUK HMGB1 IKBKB MAP3K1 NFKB1 NFKB2 NFKBIA RELA S100B

Compounds Affecting TRAF6 mediated NF-kB activation

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Resveratrol	—	298
3	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
4	Kaempferols	—	300
5	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
6	chicoric acid	—	117
7	Bortezomib	—	300
8	Podophyllotoxin	—	14
9	Rutin	—	300
10	Withania	—	500
11	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
12	tamarixetin	—	26
13	Trifluridine	—	295
14	withaferin	—	300
15	egcg	—	300
16	Disulfiram	—	297
17	streptonigrin	—	299
18	Crizotinib	—	298
19	Hydrocortisone	—	299
20	Cerulenin	—	300
21	Chlorpropamide	—	300
22	daph	—	2
23	Hexachlorophene	—	300
24	Hydrocortisone	—	298
25	Lovastatin	—	300
26	ly294002	—	11
27	Promethazine	—	121
28	protriptyline	—	296
29	Sulfaphenazole	—	300
30	Triamcinolone	—	300
31	tyrphostin 1	—	1
32	tyrphostin ag 1478	—	4
33	Hesperidin	—	300
34	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
35	Methylene Blue	—	200
36	(N-methyl-C-11)-2-(4-methylamino-phenyl)-6-hydroxybenzothiazole [Supplementary Concept] neutral analog of amyloid-binding thioflavin-T (BTA) that crosses	—	300
37	caffeic acid	—	300
38	Vitamin	—	295
39	2-Methoxyestradiol	—	300
40	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300
41	Cladribine	—	297
42	Digitoxin	—	300
43	Digoxin	—	299
44	Edetic Acid	—	24
45	Catechin	—	300
46	Vanillic Acid	—	300
47	Ouabain	—	300
48	Quinic Acid	—	218
49	Retinaldehyde	—	300
50	Voriconazole	—	299

About the TRAF6 mediated NF-kB activation Pathway

The TRAF6 mediated NF-kB activation pathway is catalogued in Reactome (ID: R-HSA-933542) and involves 10 genes. In the BiohacksAI corpus, 64 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include APP, CHUK, HMGB1, IKBKB, MAP3K1.