What compounds affect the Killing mechanisms pathway?

82 compounds in the BiohacksAI corpus have documented interactions with genes in the Killing mechanisms pathway (Reactome ID: R-HSA-9664420). These compounds target 3 genes within this pathway.

What genes are in the Killing mechanisms pathway?

The Killing mechanisms pathway involves 3 genes. Key genes include: JUN, MAPK8, NOX1.

Killing mechanisms

REACTOME PATHWAY

Reactome: R-HSA-96644203 genes82 compounds

The Killing mechanisms pathway (Reactome ID: R-HSA-9664420) involves 3 genes and is affected by 82 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

JUN MAPK8 NOX1

Compounds Affecting Killing mechanisms

#	Compound	Targets Hit	Studies
1	Colchicine	—	300
2	DEAD-box RNA Helicases	—	169
3	Thioctic Acid	—	298
4	Diphenhydramine	—	14
5	Disulfiram	—	297
6	glaucarubinone	—	10
7	Thioctic Acid	—	300
8	vinblastine sulfate	—	81
9	egcg	—	300
10	Methylene Blue	—	200
11	Amoxapine	—	259
12	Cinnarizine	—	299
13	Clofibrate	—	299
14	Ethoxyquin Antioxidant; also	—	180
15	Fenofibrate	—	297
16	Lithocholic Acid	—	300
17	Lovastatin	—	300
18	Lynestrenol	—	299
19	Medroxyprogesterone Acetate	—	299
20	Vitamin K 3	—	300
21	Mestranol	—	300
22	Phenoxybenzamine	—	21
23	Podophyllotoxin	—	14
24	Promethazine	—	121
25	triflupromazine hydrochloride	—	12
26	Vincamine	—	300
27	Azithromycin	—	1,000
28	Budesonide	—	1,000
29	Fluoxetine	—	1,000
30	Iodine	—	300
31	Mianserin	—	299
32	Sertraline	—	1,000
33	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
34	Taurine	—	300
35	vinpocetine	—	299
36	Bupranolol	—	291
37	Chlormadinone Acetate	—	300
38	Clotrimazole	—	296
39	Cyproheptadine	—	299
40	Desoxycorticosterone	—	300
41	Dihydrotestosterone	—	300
42	Dimenhydrinate	—	294
43	Dimethisterone	—	45
44	Domperidone	—	299
45	eliprodil	—	33
46	ethopropazine hydrochloride	—	2
47	Ethynodiol Diacetate	—	300
48	Fluvoxamine	—	297
49	Gemfibrozil	—	297
50	iodoform	—	272

About the Killing mechanisms Pathway

The Killing mechanisms pathway is catalogued in Reactome (ID: R-HSA-9664420) and involves 3 genes. In the BiohacksAI corpus, 82 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include JUN, MAPK8, NOX1.