What compounds affect the Signaling by ERBB2 ECD mutants pathway?

40 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by ERBB2 ECD mutants pathway (Reactome ID: R-HSA-9665348). These compounds target 6 genes within this pathway.

What genes are in the Signaling by ERBB2 ECD mutants pathway?

The Signaling by ERBB2 ECD mutants pathway involves 6 genes. Key genes include: CDC37, EGFR, ERBB2, GRB2, HSP90AA1, PIK3R1.

Signaling by ERBB2 ECD mutants

REACTOME PATHWAY

Reactome: R-HSA-96653486 genes40 compounds

The Signaling by ERBB2 ECD mutants pathway (Reactome ID: R-HSA-9665348) involves 6 genes and is affected by 40 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDC37 EGFR ERBB2 GRB2 HSP90AA1 PIK3R1

Compounds Affecting Signaling by ERBB2 ECD mutants

#	Compound	Targets Hit	Studies
1	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
2	celastrol	—	300
3	Quercetin	—	300
4	ag490	—	14
5	Wortmannin	—	300
6	Dasatinib	—	299
7	Afatinib	—	297
8	tyrphostin ag 1478	—	4
9	triolimus [Supplementary Concept]	—	33
10	monorden	—	8
11	gedunin	—	54
12	Novobiocin	—	300
13	caffeic acid	—	300
14	Masoprocol	—	300
15	Tetracycline	—	300
16	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
17	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
18	2-Chloroadenosine 2-Chloroadenosine.	—	300
19	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
20	Calcimycin	—	216
21	Calcitriol	—	300
22	Ciclopirox	—	88
23	Clotrimazole	—	296
24	cycloheximide	—	300
25	deguelin [Supplementary Concept]	—	151
26	Disulfiram	—	297
27	Hexachlorophene	—	300
28	Idarubicin	—	299
29	Indazoles	—	300
30	Miconazole	—	298
31	piceatannol	—	300
32	Nitroprusside	—	299
33	specioside	—	6
34	pictilisib	—	25
35	ly294002	—	11
36	alpelisib	—	227
37	Sirolimus	—	300
38	torin 1	—	10
39	tyrphostin 1	—	1
40	Dactinomycin	—	297

About the Signaling by ERBB2 ECD mutants Pathway

The Signaling by ERBB2 ECD mutants pathway is catalogued in Reactome (ID: R-HSA-9665348) and involves 6 genes. In the BiohacksAI corpus, 40 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDC37, EGFR, ERBB2, GRB2, HSP90AA1.