What compounds affect the Differentiation of T cells pathway?

98 compounds in the BiohacksAI corpus have documented interactions with genes in the Differentiation of T cells pathway (Reactome ID: R-HSA-9945266). These compounds target 3 genes within this pathway.

What genes are in the Differentiation of T cells pathway?

The Differentiation of T cells pathway involves 3 genes. Key genes include: IFNG, RUNX1, STAT1.

Differentiation of T cells

REACTOME PATHWAY

Reactome: R-HSA-99452663 genes98 compounds

The Differentiation of T cells pathway (Reactome ID: R-HSA-9945266) involves 3 genes and is affected by 98 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

IFNG RUNX1 STAT1

Compounds Affecting Differentiation of T cells

#	Compound	Targets Hit	Studies
1	Hexachlorophene	—	300
2	Daunorubicin	—	298
3	Dacarbazine	—	299
4	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300
5	2-Methoxyestradiol	—	300
6	Anisomycin	—	247
7	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
8	Bortezomib	—	300
9	Camptothecin	—	300
10	cycloheximide	—	300
11	Dasatinib	—	299
12	Desoxycorticosterone Acetate	—	300
13	tyrphostin 9	—	2
14	Quercetin	—	300
15	Azathioprine	—	300
16	Crizotinib	—	298
17	Econazole	—	299
18	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
19	Nocodazole Nocodazole is	—	215
20	Sorafenib	—	300
21	Ursolic Acid	—	300
22	Afatinib	—	297
23	alsterpaullone	—	12
24	Chlorhexidine	—	299
25	Cholecalciferol Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of	—	299
26	Clofarabine	—	298
27	Clotrimazole	—	296
28	Dactinomycin	—	297
29	darapladib [Supplementary Concept]	—	44
30	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
31	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
32	Epirubicin	—	300
33	Estrone	—	300
34	Ethinyl Estradiol	—	300
35	Fulvestrant	—	295
36	Idarubicin	—	299
37	Irinotecan	—	298
38	Levonorgestrel	—	292
39	Miconazole	—	298
40	Nandrolone C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less	—	300
41	Niclosamide	—	299
42	Norgestrel	—	300
43	Novobiocin	—	300
44	Perphenazine	—	297
45	Podophyllotoxin	—	14
46	scriptaid	—	53
47	Teniposide	—	299
48	Topotecan	—	300
49	Tripterygium	—	300
50	Vemurafenib	—	298

About the Differentiation of T cells Pathway

The Differentiation of T cells pathway is catalogued in Reactome (ID: R-HSA-9945266) and involves 3 genes. In the BiohacksAI corpus, 98 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include IFNG, RUNX1, STAT1.