What compounds target ATXN2?

BiohacksAI has identified 72 compounds that interact with ATXN2 (ataxin 2). Top compounds include: cycloheximide, Chlorhexidine, Ciclopirox, Oxyphenbutazone, Methylene Blue. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is ATXN2 (ataxin 2)?

ATXN2 is ataxin 2. It is a molecular target for 72 compounds documented in PubMed bioassay data. UniProt ID: Q99700. NCBI Gene ID: 6311.

ATXN2

MOLECULAR TARGET

ataxin 2

UniProt: Q99700 NCBI Gene: 631172 compounds

ATXN2 (ataxin 2) is targeted by 72 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting ATXN2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	cycloheximide	2.40	10
2	Chlorhexidine	2.20	8
3	Ciclopirox	2.20	8
4	Oxyphenbutazone	2.20	8
5	Methylene Blue	1.95	6
6	Methotrexate	1.95	6
7	Anisomycin	1.95	6
8	Fluoxetine	1.79	5
9	Calcimycin	1.79	5
10	Emetine	1.79	5
11	Maprotiline	1.79	5
12	17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterone derivative that acts as	1.61	4
13	Astemizole Antihistamine drug now withdrawn from	1.61	4
14	Azacitidine	1.61	4
15	Azacitidine	1.61	4
16	Bortezomib	1.61	4
17	Cytarabine	1.61	4
18	Dasatinib	1.61	4
19	Deslanoside Deacetyllanatoside C.	1.61	4
20	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	1.61	4
21	Digitoxin	1.61	4
22	Digoxin	1.61	4
23	Fluspirilene	1.61	4
24	Melphalan	1.61	4
25	Vitamin K 3	1.61	4
26	Ouabain	1.61	4
27	Perphenazine	1.61	4
28	Proscillaridin	1.61	4
29	Tilorone	1.61	4
30	Tubercidin	1.61	4
31	Sertraline	1.39	3
32	Clotrimazole	1.39	3
33	vinpocetine	1.10	2
34	Amoxapine	1.10	2
35	Camptothecin	1.10	2
36	Carbazilquinone	1.10	2
37	celastrol	1.10	2
38	Clofarabine	1.10	2
39	clofilium tosylate	1.10	2
40	Dactinomycin	1.10	2
41	Daunorubicin	1.10	2
42	Dinitrochlorobenzene	1.10	2
43	Disulfiram	1.10	2
44	Epirubicin	1.10	2
45	Ethidium	1.10	2
46	Evans Blue	1.10	2
47	Fluvoxamine	1.10	2
48	Hexachlorophene	1.10	2
49	Hydroxyurea	1.10	2
50	Idazoxan	1.10	2

Showing top 50 of 72 compounds. Use the BiohacksAI search to explore all ATXN2 modulators.

About ATXN2 as a Drug Target

ATXN2 (ataxin 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 72 compounds with documented ATXN2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

ATXN2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.