Question 1

What compounds target HTR7?

Accepted Answer

BiohacksAI has identified 38 compounds that interact with HTR7 (5-hydroxytryptamine receptor 7). Top compounds include: Mianserin, Aripiprazole, Metergoline, Cyproheptadine, Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

Question 2

What is HTR7 (5-hydroxytryptamine receptor 7)?

Accepted Answer

HTR7 is 5-hydroxytryptamine receptor 7. It is a molecular target for 38 compounds documented in PubMed bioassay data. UniProt ID: P34969. NCBI Gene ID: 3363.

#	Compound	Confidence	Active Assays
1	Mianserin	2.48	11
2	Aripiprazole	2.48	11
3	Metergoline	2.48	11
4	Cyproheptadine	2.08	7
5	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	1.95	6
6	Methysergide	1.95	6
7	Sumatriptan	1.95	6
8	Vortioxetine	1.95	6
9	Loxapine	1.61	4
10	Quetiapine Fumarate	1.39	3
11	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	1.39	3
12	Amoxapine	1.39	3
13	Bufotenin	1.39	3
14	Buspirone	1.39	3
15	Lisuride	1.39	3
16	Pergolide	1.39	3
17	Perphenazine	1.39	3
18	Amisulpride	1.10	2
19	Dihydroergotamine	1.10	2
20	Dihydroergotamine	1.10	2
21	Mescaline Hallucinogenic alkaloid isolated from	1.10	2
22	Phenylephrine	1.10	2
23	Astemizole Antihistamine drug now withdrawn from	0.69	1
24	Bromocriptine	0.69	1
25	Butaclamol	0.69	1
26	Carvedilol	0.69	1
27	Ergotamine	0.69	1
28	Harmaline	0.69	1
29	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	0.69	1
30	Hydroxyzine	0.69	1
31	Nortriptyline	0.69	1
32	pirenperone	0.69	1
33	Pramipexole	0.69	1
34	Quipazine	0.69	1
35	Ritonavir	0.69	1
36	Sorafenib	0.69	1
37	Tamsulosin	0.69	1
38	Yohimbine	0.69	1

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HTR7

Compounds Targeting HTR7

About HTR7 as a Drug Target