BETABiohacksAI is a research tool for informational purposes only. All outputs are computational hypothesis candidates — not confirmed mechanisms, not medical advice, and not a substitute for professional medical judgment. Independent experimental validation is always required.
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BiohacksAI/Conditions/IBS
CONDITION

Evidence-Based Compounds for IBS

Irritable bowel syndrome involves gut-brain axis dysregulation, altered gut microbiome composition, increased intestinal permeability, and visceral hypersensitivity. Compounds with clinical evidence for reducing IBS symptoms through microbiome modulation, barrier repair, anti-spasmodic action, and anti-inflammatory mechanisms are ranked below.

GUT MICROBIOME pathway →INFLAMMATION pathway →CALCIUM SIGNALING pathway →
Top 5 Compounds — Ranked by Evidence
Weighted ranking: BiohacksAI discovery score · pathway overlap · PubMed study count
1
Berberinefeatured
300+
studies
2
Magnesiumfeatured
293+
studies
3
Psylliumfeatured
266+
studies
4
Quercetinfeatured
300+
studies
5
Zincfeatured
297+
studies
Ranking Methodology
Compounds are ranked using a four-signal weighted model: BiohacksAI discovery score (cross-study convergence across targets), target match (direct overlap with TLR4, TRPV1, MUC2 and related targets — highest differentiating signal), pathway overlap with GUT MICROBIOME and INFLAMMATION pathways, and PubMed study count (log-scaled). Clinical drugs are excluded.
Key Biological Targets
TLR4TRPV1MUC2CLDN1HTR4

Click a target to see all compounds with documented interactions in the BiohacksAI corpus.

Related Health Goals
Best compounds for gut →Best compounds for inflammation →Best compounds for stress →
Related Conditions
Chronic InflammationAnxietyChronic Fatigue

This page presents computational analysis of published research from PubMed/NCBI, BindingDB, and Reactome. Rankings are based on BiohacksAI discovery score, pathway overlap, and study count. This is not medical advice — consult a healthcare professional before starting any supplement.

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