Neurotransmitter receptors and postsynaptic signal transmission

Q: What compounds affect the Neurotransmitter receptors and postsynaptic signal transmission pathway?

226 compounds in the BiohacksAI corpus have documented interactions with genes in the Neurotransmitter receptors and postsynaptic signal transmission pathway (Reactome ID: R-HSA-112314). These compounds target 89 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-11231489 genes226 compounds

The Neurotransmitter receptors and postsynaptic signal transmission pathway (Reactome ID: R-HSA-112314) involves 89 genes and is affected by 226 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADCY9 CAMK1 CAMK2B CAMK2D CAMKK1 CAMKK2 CASK CHRNA1 CHRNA4 CHRND CHRNG CREB1 ERBB4 GABBR1 GABBR2 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRG2 GABRG3 GABRQ GABRR1 GABRR2 GABRR3+59 more

Compounds Affecting Neurotransmitter receptors and postsynaptic signal transmission

#	Compound	Targets Hit	Studies
1	Colchicine	—	300
2	Nocodazole Nocodazole is	—	215
3	Picrotoxin	—	300
4	Ondansetron	—	299
5	gamma-Aminobutyric Acid	—	300
6	Demecolcine	—	246
7	Podophyllotoxin	—	14
8	vinblastine sulfate	—	81
9	Vorinostat	—	299
10	Vincristine	—	299
11	Noscapine	—	300
12	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
13	Maytansine	—	300
14	chrysin	—	300
15	Pregnanolone	—	298
16	Bicuculline	—	300
17	Etomidate Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or	—	299
18	Androsterone	—	300
19	Ciprofloxacin	—	1,000
20	Etiocholanolone	—	300
21	Triiodothyronine	—	300
22	sp600125	—	117
23	Niclosamide	—	299
24	Adenosine Monophosphate Adenine nucleotide containing	—	300
25	Glutamic Acid	—	297
26	Glutamic Acid	—	300
27	Ursolic Acid	—	300
28	Proguanil	—	299
29	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
30	Berberine	—	300
31	Antimycin	—	300
32	Oleanolic Acid	—	300
33	Rotenone	—	300
34	Metformin	—	1,000
35	Aripiprazole	—	298
36	Ethidium	—	300
37	Sorafenib	—	300
38	Eszopiclone	—	296
39	hydroxyfasudil [Supplementary Concept]	—	11
40	alsterpaullone	—	12
41	Spermine	—	300
42	Quipazine	—	300
43	Metoclopramide	—	297
44	Mianserin	—	299
45	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid	—	300
46	Quercetin	—	300
47	Dasatinib	—	299
48	tyrphostin ag 1478	—	4
49	kenpaullone	—	8
50	fisetin	—	78

About the Neurotransmitter receptors and postsynaptic signal transmission Pathway

The Neurotransmitter receptors and postsynaptic signal transmission pathway is catalogued in Reactome (ID: R-HSA-112314) and involves 89 genes. In the BiohacksAI corpus, 226 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADCY9, CAMK1, CAMK2B, CAMK2D, CAMKK1.