What compounds affect the RAF-independent MAPK1/3 activation pathway?

55 compounds in the BiohacksAI corpus have documented interactions with genes in the RAF-independent MAPK1/3 activation pathway (Reactome ID: R-HSA-112409). These compounds target 9 genes within this pathway.

What genes are in the RAF-independent MAPK1/3 activation pathway?

The RAF-independent MAPK1/3 activation pathway involves 9 genes. Key genes include: CDK1, DUSP5, IL6, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK3, TYK2.

RAF-independent MAPK1/3 activation

REACTOME PATHWAY

Reactome: R-HSA-1124099 genes55 compounds

The RAF-independent MAPK1/3 activation pathway (Reactome ID: R-HSA-112409) involves 9 genes and is affected by 55 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDK1 DUSP5 IL6 JAK2 MAP2K1 MAP2K2 MAPK1 MAPK3 TYK2

Compounds Affecting RAF-independent MAPK1/3 activation

#	Compound	Targets Hit	Studies
1	pd98059	—	7
2	Sorafenib	—	300
3	trametinib	—	296
4	alsterpaullone	—	12
5	kenpaullone	—	8
6	sp600125	—	117
7	Dasatinib	—	299
8	Axitinib	—	298
9	plumbagin [Supplementary Concept]	—	300
10	Clotrimazole	—	296
11	fisetin	—	78
12	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
13	withaferin	—	300
14	Vemurafenib	—	298
15	tyrphostin ag 1478	—	4
16	Progesterone	—	299
17	2-Chloroadenosine 2-Chloroadenosine.	—	300
18	Benzalkonium Compounds	—	299
19	Calcimycin	—	216
20	daph	—	2
21	Diphenhydramine	—	14
22	ha1004	—	4
23	Lithocholic Acid	—	300
24	Loratadine	—	296
25	trequinsin hydrochloride	—	1
26	indirubin	—	300
27	Clofibrate	—	299
28	Fenofibrate	—	297
29	Sertraline	—	1,000
30	Cinnarizine	—	299
31	Rotenone	—	300
32	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
33	chrysin	—	300
34	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
35	Quercetin	—	300
36	Azauridine	—	300
37	Cladribine	—	297
38	Methylene Blue	—	200
39	2-Methoxyestradiol	—	300
40	Astemizole Antihistamine drug now withdrawn from	—	280
41	Azathioprine	—	300
42	Calcitriol	—	300
43	Camptothecin	—	300
44	Cytarabine	—	297
45	dihydrorotenone	—	13
46	Podophyllotoxin	—	14
47	streptonigrin	—	299
48	Trifluridine	—	295
49	Tripterygium	—	300
50	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300

About the RAF-independent MAPK1/3 activation Pathway

The RAF-independent MAPK1/3 activation pathway is catalogued in Reactome (ID: R-HSA-112409) and involves 9 genes. In the BiohacksAI corpus, 55 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDK1, DUSP5, IL6, JAK2, MAP2K1.