What compounds affect the ER-Phagosome pathway pathway?

59 compounds in the BiohacksAI corpus have documented interactions with genes in the ER-Phagosome pathway pathway (Reactome ID: R-HSA-1236974). These compounds target 43 genes within this pathway.

What genes are in the ER-Phagosome pathway pathway?

The ER-Phagosome pathway pathway involves 43 genes. Key genes include: ADRM1, BTK, CHUK, HLA-A, HLA-B, HMGB1, IKBKB, PDIA3, PSMA1, PSMA2.

ER-Phagosome pathway

REACTOME PATHWAY

Reactome: R-HSA-123697443 genes59 compounds

The ER-Phagosome pathway pathway (Reactome ID: R-HSA-1236974) involves 43 genes and is affected by 59 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 BTK CHUK HLA-A HLA-B HMGB1 IKBKB PDIA3 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5+13 more

Compounds Affecting ER-Phagosome pathway

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Crizotinib	—	298
4	Disulfiram	—	297
5	Genistein	—	300
6	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
7	chicoric acid	—	117
8	Camptothecin	—	300
9	Ouabain	—	300
10	withaferin	—	300
11	celastrol	—	300
12	Idarubicin	—	299
13	Azacitidine	—	298
14	Azacitidine	—	300
15	Calcimycin	—	216
16	cycloheximide	—	300
17	Dactinomycin	—	297
18	Daunorubicin	—	298
19	Emetine	—	298
20	Epirubicin	—	300
21	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300
22	3-(1-(3-hydroxy-4-methoxyphenyl)methylidene)-6-methylchroman-4-one [Supplementary Concept]	—	1
23	kenpaullone	—	8
24	Proscillaridin	—	219
25	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
26	Tripterygium	—	300
27	cbd	—	298
28	Sertraline	—	1,000
29	cannabidiol	—	296
30	Deslanoside Deacetyllanatoside C.	—	89
31	Digitoxin	—	300
32	Digoxin	—	299
33	Feprazone	—	63
34	Leflunomide	—	297
35	Nitrendipine	—	299
36	Phenylbutazone	—	300
37	triolimus [Supplementary Concept]	—	33
38	Thapsigargin	—	300
39	4-Hydroxybenzoate-3-Monooxygenase	—	300
40	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
41	chrysin	—	300
42	egcg	—	300
43	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
44	Quercetin	—	300
45	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
46	alsterpaullone	—	12
47	Aurintricarboxylic Acid	—	184
48	sp600125	—	117
49	Dasatinib	—	299
50	tyrphostin ag 1478	—	4

About the ER-Phagosome pathway Pathway

The ER-Phagosome pathway pathway is catalogued in Reactome (ID: R-HSA-1236974) and involves 43 genes. In the BiohacksAI corpus, 59 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, BTK, CHUK, HLA-A, HLA-B.