What genes are in the Antigen processing-Cross presentation pathway?

The Antigen processing-Cross presentation pathway involves 47 genes. Key genes include: ADRM1, BTK, CHUK, CTSL, CYBB, HLA-A, HLA-B, HMGB1, IKBKB, ITGAV.

Antigen processing-Cross presentation

Q: What compounds affect the Antigen processing-Cross presentation pathway?

65 compounds in the BiohacksAI corpus have documented interactions with genes in the Antigen processing-Cross presentation pathway (Reactome ID: R-HSA-1236975). These compounds target 47 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-123697547 genes65 compounds

The Antigen processing-Cross presentation pathway (Reactome ID: R-HSA-1236975) involves 47 genes and is affected by 65 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 BTK CHUK CTSL CYBB HLA-A HLA-B HMGB1 IKBKB ITGAV NCF1 PDIA3 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1+17 more

Compounds Affecting Antigen processing-Cross presentation

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Crizotinib	—	298
4	celastrol	—	300
5	Disulfiram	—	297
6	Genistein	—	300
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	chrysin	—	300
9	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
10	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
11	chicoric acid	—	117
12	Camptothecin	—	300
13	Ouabain	—	300
14	withaferin	—	300
15	Idarubicin	—	299
16	Azacitidine	—	298
17	Azacitidine	—	300
18	Calcimycin	—	216
19	cycloheximide	—	300
20	Dactinomycin	—	297
21	Daunorubicin	—	298
22	Emetine	—	298
23	Epirubicin	—	300
24	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300
25	3-(1-(3-hydroxy-4-methoxyphenyl)methylidene)-6-methylchroman-4-one [Supplementary Concept]	—	1
26	kenpaullone	—	8
27	Proscillaridin	—	219
28	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
29	Tripterygium	—	300
30	cbd	—	298
31	Sertraline	—	1,000
32	cannabidiol	—	296
33	Deslanoside Deacetyllanatoside C.	—	89
34	Digitoxin	—	300
35	Digoxin	—	299
36	Feprazone	—	63
37	Leflunomide	—	297
38	Nitrendipine	—	299
39	Phenylbutazone	—	300
40	triolimus [Supplementary Concept]	—	33
41	Thapsigargin	—	300
42	4-Hydroxybenzoate-3-Monooxygenase	—	300
43	egcg	—	300
44	Quercetin	—	300
45	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
46	Naloxone	—	299
47	alsterpaullone	—	12
48	Aurintricarboxylic Acid	—	184
49	sp600125	—	117
50	Methylene Blue	—	200

About the Antigen processing-Cross presentation Pathway

The Antigen processing-Cross presentation pathway is catalogued in Reactome (ID: R-HSA-1236975) and involves 47 genes. In the BiohacksAI corpus, 65 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, BTK, CHUK, CTSL, CYBB.