What compounds affect the Phospholipid metabolism pathway?

113 compounds in the BiohacksAI corpus have documented interactions with genes in the Phospholipid metabolism pathway (Reactome ID: R-HSA-1483257). These compounds target 30 genes within this pathway.

What genes are in the Phospholipid metabolism pathway?

The Phospholipid metabolism pathway involves 30 genes. Key genes include: ACHE, BCHE, BMX, CSNK2A1, CSNK2A2, CSNK2B, INPPL1, MGLL, PHOSPHO1, PI4K2A.

Phospholipid metabolism

REACTOME PATHWAY

Reactome: R-HSA-148325730 genes113 compounds

The Phospholipid metabolism pathway (Reactome ID: R-HSA-1483257) involves 30 genes and is affected by 113 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ACHE BCHE BMX CSNK2A1 CSNK2A2 CSNK2B INPPL1 MGLL PHOSPHO1 PI4K2A PI4K2B PI4KA PI4KB PIK3C2A PIK3C2B PIK3C2G PIK3C3 PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIP4K2A PIP5K1A PLA2G1B PLA2G3 PLD2 SYNJ2

Compounds Affecting Phospholipid metabolism

#	Compound	Targets Hit	Studies
1	pictilisib	—	25
2	ly294002	—	11
3	Wortmannin	—	300
4	Quercetin	—	300
5	torin 1	—	10
6	Sirolimus	—	300
7	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
8	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
9	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
10	fisetin	—	78
11	Kaempferols	—	300
12	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
13	alpelisib	—	227
14	Disulfiram	—	297
15	chrysin	—	300
16	Vanillic Acid	—	300
17	Crizotinib	—	298
18	Physostigmine	—	300
19	Physostigmine	—	299
20	Chlorhexidine	—	299
21	Berberine	—	300
22	ethopropazine	—	17
23	Hexachlorophene	—	300
24	Reserpine	—	297
25	piceatannol	—	300
26	Adenosine	—	298
27	bis(12)-hupyridone [Supplementary Concept]	—	300
28	Methylene Blue	—	200
29	Ranitidine	—	299
30	Ethidium	—	300
31	Metergoline	—	144
32	Nicergoline	—	300
33	Progesterone	—	299
34	Phenylglyoxal	—	300
35	Procainamide	—	297
36	Tilorone	—	300
37	Acetaldehyde	—	300
38	Carbaryl	—	300
39	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
40	Dihydroergotamine	—	299
41	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	—	298
42	Methysergide	—	300
43	Promethazine	—	121
44	Thioridazine	—	35
45	Caffeine	—	299
46	Amisulpride	—	298
47	Astemizole Antihistamine drug now withdrawn from	—	280
48	Hyoscyamine	—	296
49	Dinitrochlorobenzene	—	300
50	Edaravone	—	298

About the Phospholipid metabolism Pathway

The Phospholipid metabolism pathway is catalogued in Reactome (ID: R-HSA-1483257) and involves 30 genes. In the BiohacksAI corpus, 113 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ACHE, BCHE, BMX, CSNK2A1, CSNK2A2.