What compounds affect the Synthesis of bile acids and bile salts pathway?

163 compounds in the BiohacksAI corpus have documented interactions with genes in the Synthesis of bile acids and bile salts pathway (Reactome ID: R-HSA-192105). These compounds target 11 genes within this pathway.

What genes are in the Synthesis of bile acids and bile salts pathway?

The Synthesis of bile acids and bile salts pathway involves 11 genes. Key genes include: ABCB11, AKR1C1, AKR1C2, AKR1C3, AKR1C4, CYP46A1, CYP8B1, NCOA1, NR1H4, OSBP.

Synthesis of bile acids and bile salts

REACTOME PATHWAY

Reactome: R-HSA-19210511 genes163 compounds

The Synthesis of bile acids and bile salts pathway (Reactome ID: R-HSA-192105) involves 11 genes and is affected by 163 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCB11 AKR1C1 AKR1C2 AKR1C3 AKR1C4 CYP46A1 CYP8B1 NCOA1 NR1H4 OSBP RXRA

Compounds Affecting Synthesis of bile acids and bile salts

#	Compound	Targets Hit	Studies
1	Progesterone	—	299
2	Rotenone	—	300
3	Clotrimazole	—	296
4	Medroxyprogesterone Acetate	—	299
5	Chenodeoxycholic Acid	—	299
6	Genistein	—	300
7	Ursodeoxycholic Acid	—	298
8	Cholic Acid	—	299
9	Ethidium	—	300
10	Ethinyl Estradiol	—	300
11	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
12	Methylene Blue	—	200
13	Dactinomycin	—	297
14	Mometasone Furoate	—	292
15	chrysin	—	300
16	Thyroxine	—	994
17	Simvastatin	—	1,000
18	Methotrexate	—	289
19	Azacitidine	—	298
20	Azacitidine	—	300
21	Dihydrotestosterone	—	300
22	Glycochenodeoxycholic Acid	—	300
23	Retinaldehyde	—	300
24	Taurochenodeoxycholic Acid	—	300
25	Thyroxine	—	300
26	Troglitazone	—	299
27	Testosterone	—	299
28	Econazole	—	299
29	Miconazole	—	298
30	Naproxen	—	1,000
31	Berberine	—	300
32	Cholesterol	—	300
33	obeticholic acid [Supplementary Concept]	—	271
34	Lithocholic Acid	—	300
35	Resveratrol	—	298
36	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
37	Colchicine	—	300
38	Chlormadinone Acetate	—	300
39	Daunorubicin	—	298
40	Decitabine	—	298
41	Finasteride	—	296
42	Fulvestrant	—	295
43	Itraconazole	—	297
44	Podophyllotoxin	—	14
45	trequinsin hydrochloride	—	1
46	vinblastine sulfate	—	81
47	Atorvastatin	—	1,000
48	Dehydroepiandrosterone	—	300
49	Adapalene	—	296
50	Chlorhexidine	—	299

About the Synthesis of bile acids and bile salts Pathway

The Synthesis of bile acids and bile salts pathway is catalogued in Reactome (ID: R-HSA-192105) and involves 11 genes. In the BiohacksAI corpus, 163 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCB11, AKR1C1, AKR1C2, AKR1C3, AKR1C4.