Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

Q: What compounds affect the Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway?

161 compounds in the BiohacksAI corpus have documented interactions with genes in the Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway (Reactome ID: R-HSA-193368). These compounds target 9 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-1933689 genes161 compounds

The Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway (Reactome ID: R-HSA-193368) involves 9 genes and is affected by 161 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCB11 AKR1C1 AKR1C2 AKR1C3 AKR1C4 CYP8B1 NCOA1 NR1H4 RXRA

Compounds Affecting Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

#	Compound	Targets Hit	Studies
1	Progesterone	—	299
2	Rotenone	—	300
3	Clotrimazole	—	296
4	Medroxyprogesterone Acetate	—	299
5	Chenodeoxycholic Acid	—	299
6	Genistein	—	300
7	Ursodeoxycholic Acid	—	298
8	Cholic Acid	—	299
9	Ethidium	—	300
10	Ethinyl Estradiol	—	300
11	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
12	Methylene Blue	—	200
13	Dactinomycin	—	297
14	Mometasone Furoate	—	292
15	chrysin	—	300
16	Thyroxine	—	994
17	Simvastatin	—	1,000
18	Methotrexate	—	289
19	Azacitidine	—	298
20	Azacitidine	—	300
21	Dihydrotestosterone	—	300
22	Glycochenodeoxycholic Acid	—	300
23	Retinaldehyde	—	300
24	Taurochenodeoxycholic Acid	—	300
25	Thyroxine	—	300
26	Troglitazone	—	299
27	Testosterone	—	299
28	Econazole	—	299
29	Miconazole	—	298
30	Naproxen	—	1,000
31	Berberine	—	300
32	obeticholic acid [Supplementary Concept]	—	271
33	Lithocholic Acid	—	300
34	Resveratrol	—	298
35	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
36	Colchicine	—	300
37	Chlormadinone Acetate	—	300
38	Daunorubicin	—	298
39	Decitabine	—	298
40	Finasteride	—	296
41	Fulvestrant	—	295
42	Itraconazole	—	297
43	Podophyllotoxin	—	14
44	trequinsin hydrochloride	—	1
45	vinblastine sulfate	—	81
46	Atorvastatin	—	1,000
47	Dehydroepiandrosterone	—	300
48	Adapalene	—	296
49	Chlorhexidine	—	299
50	Deferasirox	—	298

About the Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Pathway

The Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway is catalogued in Reactome (ID: R-HSA-193368) and involves 9 genes. In the BiohacksAI corpus, 161 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCB11, AKR1C1, AKR1C2, AKR1C3, AKR1C4.