Metabolism of water-soluble vitamins and cofactors

Q: What compounds affect the Metabolism of water-soluble vitamins and cofactors pathway?

102 compounds in the BiohacksAI corpus have documented interactions with genes in the Metabolism of water-soluble vitamins and cofactors pathway (Reactome ID: R-HSA-196849). These compounds target 22 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-19684922 genes102 compounds

The Metabolism of water-soluble vitamins and cofactors pathway (Reactome ID: R-HSA-196849) involves 22 genes and is affected by 102 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AASDHPPT ABCC1 AOX1 CD38 CTRB1 DHFR ENPP2 FASN FPGS GSTO1 NADK NAPRT NNMT PDXK PRSS1 PRSS3 SHMT2 SLC19A1 SLC23A1 SLC2A1 SLC2A3 SLC46A1

Compounds Affecting Metabolism of water-soluble vitamins and cofactors

#	Compound	Targets Hit	Studies
1	Methotrexate	—	289
2	Pemetrexed	—	299
3	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
4	egcg	—	300
5	Leucovorin	—	297
6	Bortezomib	—	300
7	Calcimycin	—	216
8	Quercetin	—	300
9	Kaempferols	—	300
10	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
11	Vitamin K 3	—	300
12	Genistein	—	300
13	Resveratrol	—	298
14	Glucose	—	294
15	Sulfaguanidine	—	255
16	Crizotinib	—	298
17	Dequalinium	—	136
18	Ticagrelor	—	299
19	tyrphostin ag 1478	—	4
20	Aurintricarboxylic Acid	—	184
21	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
22	Chlorhexidine	—	299
23	Cisplatin	—	300
24	darapladib [Supplementary Concept]	—	44
25	Dasatinib	—	299
26	Demeclocycline	—	297
27	Iodoacetamide	—	300
28	pictilisib	—	25
29	Vemurafenib	—	298
30	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
31	Thyroxine	—	994
32	same	—	299
33	2-Methoxyestradiol	—	300
34	6-Aminonicotinamide	—	300
35	Afatinib	—	297
36	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
37	Disulfiram	—	297
38	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
39	Estrone	—	300
40	Guanabenz	—	298
41	Methyldopa	—	297
42	Methylergonovine	—	193
43	Methysergide	—	300
44	piceatannol	—	300
45	propionylpromazine hydrochloride	—	2
46	s adenosylmethionine	—	300
47	scriptaid	—	53
48	Suramin	—	300
49	Thiorphan	—	300
50	Thyroxine	—	300

About the Metabolism of water-soluble vitamins and cofactors Pathway

The Metabolism of water-soluble vitamins and cofactors pathway is catalogued in Reactome (ID: R-HSA-196849) and involves 22 genes. In the BiohacksAI corpus, 102 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AASDHPPT, ABCC1, AOX1, CD38, CTRB1.