What compounds affect the FCGR activation pathway?

208 compounds in the BiohacksAI corpus have documented interactions with genes in the FCGR activation pathway (Reactome ID: R-HSA-2029481). These compounds target 7 genes within this pathway.

What genes are in the FCGR activation pathway?

The FCGR activation pathway involves 7 genes. Key genes include: FGR, FYN, HCK, LYN, SRC, SYK, YES1.

FCGR activation

REACTOME PATHWAY

Reactome: R-HSA-20294817 genes208 compounds

The FCGR activation pathway (Reactome ID: R-HSA-2029481) involves 7 genes and is affected by 208 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

FGR FYN HCK LYN SRC SYK YES1

Compounds Affecting FCGR activation

#	Compound	Targets Hit	Studies
1	Dasatinib	—	299
2	tyrphostin ag 1478	—	4
3	Sorafenib	—	300
4	Crizotinib	—	298
5	kenpaullone	—	8
6	Axitinib	—	298
7	Afatinib	—	297
8	Quercetin	—	300
9	alsterpaullone	—	12
10	sp600125	—	117
11	Niclosamide	—	299
12	Cladribine	—	297
13	monorden	—	8
14	pictilisib	—	25
15	Vemurafenib	—	298
16	Kaempferols	—	300
17	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
18	Ouabain	—	300
19	Atorvastatin	—	1,000
20	Simvastatin	—	1,000
21	Methotrexate	—	289
22	Chlorhexidine	—	299
23	Clofarabine	—	298
24	Colchicine	—	300
25	cycloheximide	—	300
26	deguelin [Supplementary Concept]	—	151
27	Digoxin	—	299
28	Disulfiram	—	297
29	Emetine	—	298
30	Ezetimibe	—	296
31	Lovastatin	—	300
32	Medroxyprogesterone Acetate	—	299
33	Melphalan	—	300
34	Mometasone Furoate	—	292
35	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
36	piceatannol	—	300
37	Podophyllotoxin	—	14
38	Thapsigargin	—	300
39	torin 1	—	10
40	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
41	Trifluridine	—	295
42	fisetin	—	78
43	ag490	—	14
44	alpelisib	—	227
45	Azathioprine	—	300
46	Bortezomib	—	300
47	Maprotiline	—	299
48	Nocodazole Nocodazole is	—	215
49	N-pyridazin-3-yl-4-(3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzylidene)piperidine-1-carboxamide [Supplementary Concept]	—	8
50	Tripterygium	—	300

About the FCGR activation Pathway

The FCGR activation pathway is catalogued in Reactome (ID: R-HSA-2029481) and involves 7 genes. In the BiohacksAI corpus, 208 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include FGR, FYN, HCK, LYN, SRC.