What genes are in the YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway?

The YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway involves 5 genes. Key genes include: HIPK1, HIPK2, KAT2B, TEAD4, YAP1.

YAP1- and WWTR1 (TAZ)-stimulated gene expression

Q: What compounds affect the YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway?

49 compounds in the BiohacksAI corpus have documented interactions with genes in the YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway (Reactome ID: R-HSA-2032785). These compounds target 5 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-20327855 genes49 compounds

The YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway (Reactome ID: R-HSA-2032785) involves 5 genes and is affected by 49 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

HIPK1 HIPK2 KAT2B TEAD4 YAP1

Compounds Affecting YAP1- and WWTR1 (TAZ)-stimulated gene expression

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	pictilisib	—	25
3	Colchicine	—	300
4	Resveratrol	—	298
5	Daunorubicin	—	298
6	Rotenone	—	300
7	Pueraria	—	300
8	Azacitidine	—	298
9	Azacitidine	—	300
10	Camptothecin	—	300
11	cycloheximide	—	300
12	Dactinomycin	—	297
13	deguelin [Supplementary Concept]	—	151
14	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
15	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
16	Ouabain	—	300
17	Podophyllotoxin	—	14
18	Thapsigargin	—	300
19	Berberine	—	300
20	Genistein	—	300
21	2-Methoxyestradiol	—	300
22	Anisomycin	—	247
23	Antimycin	—	300
24	Azauridine	—	300
25	Benzalkonium Compounds	—	299
26	celastrol	—	300
27	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
28	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
29	dihydrorotenone	—	13
30	Emetine	—	298
31	Gliotoxin	—	300
32	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300
33	Monensin	—	300
34	Monocrotaline	—	300
35	Nigericin	—	300
36	Nocodazole Nocodazole is	—	215
37	Plicamycin	—	72
38	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
39	Tilorone	—	300
40	Tripterygium	—	300
41	Tubercidin	—	300
42	tyrphostin 9	—	2
43	Valinomycin	—	300
44	sp600125	—	117
45	ly294002	—	11
46	np1	—	81
47	egcg	—	300
48	plumbagin [Supplementary Concept]	—	300
49	Niflumic Acid	—	300

About the YAP1- and WWTR1 (TAZ)-stimulated gene expression Pathway

The YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway is catalogued in Reactome (ID: R-HSA-2032785) and involves 5 genes. In the BiohacksAI corpus, 49 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include HIPK1, HIPK2, KAT2B, TEAD4, YAP1.