Binding and Uptake of Ligands by Scavenger Receptors

Q: What compounds affect the Binding and Uptake of Ligands by Scavenger Receptors pathway?

52 compounds in the BiohacksAI corpus have documented interactions with genes in the Binding and Uptake of Ligands by Scavenger Receptors pathway (Reactome ID: R-HSA-2173782). These compounds target 8 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-21737828 genes52 compounds

The Binding and Uptake of Ligands by Scavenger Receptors pathway (Reactome ID: R-HSA-2173782) involves 8 genes and is affected by 52 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ALB HBA1 HBA2 HBB HMGB1 HSP90AA1 HSP90B1 PRDX1

Compounds Affecting Binding and Uptake of Ligands by Scavenger Receptors

#	Compound	Targets Hit	Studies
1	diallyl trisulfide	—	246
2	2-Chloroadenosine 2-Chloroadenosine.	—	300
3	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
4	triolimus [Supplementary Concept]	—	33
5	monorden	—	8
6	gedunin	—	54
7	celastrol	—	300
8	Novobiocin	—	300
9	caffeic acid	—	300
10	Masoprocol	—	300
11	Tetracycline	—	300
12	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
13	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
14	Quercetin	—	300
15	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
16	ag490	—	14
17	Calcimycin	—	216
18	Calcitriol	—	300
19	Ciclopirox	—	88
20	Clotrimazole	—	296
21	cycloheximide	—	300
22	deguelin [Supplementary Concept]	—	151
23	Disulfiram	—	297
24	Hexachlorophene	—	300
25	Idarubicin	—	299
26	Indazoles	—	300
27	Miconazole	—	298
28	piceatannol	—	300
29	Nitroprusside	—	299
30	specioside	—	6
31	Wortmannin	—	300
32	Warfarin	—	1,000
33	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
34	Tolbutamide	—	300
35	cbd	—	298
36	egcg	—	300
37	cannabidiol	—	296
38	Catechin	—	300
39	Evans Blue	—	300
40	Olmesartan Medoxomil	—	300
41	Phenylbutazone	—	300
42	Trazodone	—	297
43	Azathioprine	—	300
44	Azacitidine	—	298
45	Azacitidine	—	300
46	Camptothecin	—	300
47	Vitamin K 3	—	300
48	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
49	Adenosine Triphosphate	—	300
50	Methotrexate	—	289

About the Binding and Uptake of Ligands by Scavenger Receptors Pathway

The Binding and Uptake of Ligands by Scavenger Receptors pathway is catalogued in Reactome (ID: R-HSA-2173782) and involves 8 genes. In the BiohacksAI corpus, 52 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ALB, HBA1, HBA2, HBB, HMGB1.