What compounds affect the Visual phototransduction pathway?

52 compounds in the BiohacksAI corpus have documented interactions with genes in the Visual phototransduction pathway (Reactome ID: R-HSA-2187338). These compounds target 16 genes within this pathway.

What genes are in the Visual phototransduction pathway?

The Visual phototransduction pathway involves 16 genes. Key genes include: AKR1B10, AKR1C1, AKR1C3, AKR1C4, CHURC1-FNTB, CNGA1, FNTA, FNTB, GRK4, HSD17B1.

Visual phototransduction

REACTOME PATHWAY

Reactome: R-HSA-218733816 genes52 compounds

The Visual phototransduction pathway (Reactome ID: R-HSA-2187338) involves 16 genes and is affected by 52 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AKR1B10 AKR1C1 AKR1C3 AKR1C4 CHURC1-FNTB CNGA1 FNTA FNTB GRK4 HSD17B1 METAP1 OPN1LW PDE6A PNLIP RBP4 TTR

Compounds Affecting Visual phototransduction

#	Compound	Targets Hit	Studies
1	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
2	Kaempferols	—	300
3	Gliotoxin	—	300
4	Lovastatin	—	300
5	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
6	egcg	—	300
7	Masoprocol	—	300
8	Genistein	—	300
9	Vitamin	—	295
10	Quercetin	—	300
11	Medroxyprogesterone Acetate	—	299
12	Niflumic Acid	—	300
13	Thyroxine	—	994
14	pterostilbene	—	299
15	piceatannol	—	300
16	Thyroxine	—	300
17	Resveratrol	—	298
18	Rosmarinic Acid	—	300
19	Dextrothyroxine	—	134
20	Gemfibrozil	—	297
21	Triiodothyronine	—	300
22	Oleanolic Acid	—	300
23	Ursolic Acid	—	300
24	Chlorogenic Acid	—	300
25	caffeic acid	—	300
26	Pueraria	—	300
27	Rutin	—	300
28	Hesperidin	—	300
29	phlorhizin	—	224
30	Sulindac	—	297
31	alphitonin [Supplementary Concept] from	—	300
32	Pennisetum	—	291
33	Estrone	—	300
34	Kaempferols	—	300
35	Indomethacin	—	297
36	Naproxen	—	1,000
37	Berberine	—	300
38	Linoleic Acid	—	300
39	Bimatoprost	—	297
40	chrysin	—	300
41	Progesterone	—	299
42	Testosterone	—	299
43	Equilin	—	216
44	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
45	rafoxanide	—	172
46	Axitinib	—	298
47	Crizotinib	—	298
48	Cyclic GMP Guanosine cyclic 3',5'-(hydrogen phosphate).	—	300
49	Dequalinium	—	136
50	Antazoline	—	229

About the Visual phototransduction Pathway

The Visual phototransduction pathway is catalogued in Reactome (ID: R-HSA-2187338) and involves 16 genes. In the BiohacksAI corpus, 52 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKR1B10, AKR1C1, AKR1C3, AKR1C4, CHURC1-FNTB.