What compounds affect the Oncogene Induced Senescence pathway?

184 compounds in the BiohacksAI corpus have documented interactions with genes in the Oncogene Induced Senescence pathway (Reactome ID: R-HSA-2559585). These compounds target 7 genes within this pathway.

What genes are in the Oncogene Induced Senescence pathway?

The Oncogene Induced Senescence pathway involves 7 genes. Key genes include: CDK4, CDK6, MAPK1, MAPK3, MDM2, MDM4, TP53.

Oncogene Induced Senescence

REACTOME PATHWAY

Reactome: R-HSA-25595857 genes184 compounds

The Oncogene Induced Senescence pathway (Reactome ID: R-HSA-2559585) involves 7 genes and is affected by 184 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDK4 CDK6 MAPK1 MAPK3 MDM2 MDM4 TP53

Compounds Affecting Oncogene Induced Senescence

#	Compound	Targets Hit	Studies
1	sp600125	—	117
2	Hexachlorophene	—	300
3	Azacitidine	—	298
4	Azacitidine	—	300
5	Methylene Blue	—	200
6	Cladribine	—	297
7	Cytarabine	—	297
8	Melphalan	—	300
9	Niclosamide	—	299
10	Methotrexate	—	289
11	Trifluridine	—	295
12	plumbagin [Supplementary Concept]	—	300
13	Ciclopirox	—	88
14	cycloheximide	—	300
15	Dinitrochlorobenzene	—	300
16	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
17	Vorinostat	—	299
18	Spironolactone	—	298
19	Thioridazine	—	35
20	vinblastine sulfate	—	81
21	Digoxin	—	299
22	Nisoldipine	—	297
23	Nocodazole Nocodazole is	—	215
24	Oxyphenbutazone	—	300
25	pd98059	—	7
26	rafoxanide	—	172
27	Sertraline	—	1,000
28	Astemizole Antihistamine drug now withdrawn from	—	280
29	Chlorhexidine	—	299
30	Colchicine	—	300
31	Demecolcine	—	246
32	tyrphostin 9	—	2
33	withaferin	—	300
34	Calcimycin	—	216
35	Sorafenib	—	300
36	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
37	daph	—	2
38	Loratadine	—	296
39	Clotrimazole	—	296
40	chrysin	—	300
41	Benzalkonium Compounds	—	299
42	Progesterone	—	299
43	2-Chloroadenosine 2-Chloroadenosine.	—	300
44	Nitrofurantoin	—	297
45	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
46	Tubercidin	—	300
47	Anisomycin	—	247
48	colchine	—	2
49	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
50	Fluspirilene	—	74

About the Oncogene Induced Senescence Pathway

The Oncogene Induced Senescence pathway is catalogued in Reactome (ID: R-HSA-2559585) and involves 7 genes. In the BiohacksAI corpus, 184 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDK4, CDK6, MAPK1, MAPK3, MDM2.