What compounds affect the Stimuli-sensing channels pathway?

66 compounds in the BiohacksAI corpus have documented interactions with genes in the Stimuli-sensing channels pathway (Reactome ID: R-HSA-2672351). These compounds target 22 genes within this pathway.

What genes are in the Stimuli-sensing channels pathway?

The Stimuli-sensing channels pathway involves 22 genes. Key genes include: ASIC3, ASPH, FKBP1B, RAF1, RIPK3, RYR1, RYR2, RYR3, SGK1, SGK2.

Stimuli-sensing channels

REACTOME PATHWAY

Reactome: R-HSA-267235122 genes66 compounds

The Stimuli-sensing channels pathway (Reactome ID: R-HSA-2672351) involves 22 genes and is affected by 66 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ASIC3 ASPH FKBP1B RAF1 RIPK3 RYR1 RYR2 RYR3 SGK1 SGK2 TRPC5 TRPC6 TRPM2 TRPM3 TRPM4 TRPM5 TRPM7 TRPM8 TRPV1 TRPV2 TRPV5 TSC22D3

Compounds Affecting Stimuli-sensing channels

#	Compound	Targets Hit	Studies
1	Adenosine Triphosphate	—	300
2	Lysophosphatidylcholines Derivatives of PHOSPHATIDYLCHOLINES obtained by their partial hydrolysis which removes	—	300
3	Clotrimazole	—	296
4	Econazole	—	299
5	Spermine	—	300
6	cbd	—	298
7	cannabidiol	—	296
8	Caffeine	—	299
9	Dantrolene Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in	—	298
10	Ryanodine	—	299
11	Arachidonic Acid	—	245
12	Adenosine Monophosphate Adenine nucleotide containing	—	300
13	Miconazole	—	298
14	Sphingosine	—	300
15	Suramin	—	300
16	Vemurafenib	—	298
17	sp600125	—	117
18	Hyoscyamine	—	296
19	Carvedilol	—	296
20	Propantheline	—	73
21	Methylene Blue	—	200
22	Hexachlorophene	—	300
23	Promazine	—	40
24	Promethazine	—	121
25	propionylpromazine hydrochloride	—	2
26	Thioridazine	—	35
27	triflupromazine hydrochloride	—	12
28	Duloxetine Hydrochloride	—	993
29	Amoxapine	—	259
30	Fluspirilene	—	74
31	NAD	—	300
32	NAD	—	300
33	NAD	—	300
34	Cyclic ADP-Ribose	—	300
35	Adenosine Diphosphate Ribose	—	300
36	O-Acetyl-ADP-Ribose	—	92
37	Colchicine	—	300
38	Cyclic AMP	—	300
39	Cyclic AMP	—	300
40	Emetine	—	298
41	Lasalocid Cationic ionophore antibiotic obtained from Streptomyces lasaliensis that, among other effects, dissociates	—	300
42	Pueraria	—	300
43	Genistein	—	300
44	Kaempferols	—	300
45	Progesterone	—	299
46	Quercetin	—	300
47	m084	—	2
48	Adenosine	—	298
49	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
50	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300

About the Stimuli-sensing channels Pathway

The Stimuli-sensing channels pathway is catalogued in Reactome (ID: R-HSA-2672351) and involves 22 genes. In the BiohacksAI corpus, 66 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ASIC3, ASPH, FKBP1B, RAF1, RIPK3.