What compounds affect the CD28 dependent PI3K/Akt signaling pathway?

45 compounds in the BiohacksAI corpus have documented interactions with genes in the CD28 dependent PI3K/Akt signaling pathway (Reactome ID: R-HSA-389357). These compounds target 15 genes within this pathway.

What genes are in the CD28 dependent PI3K/Akt signaling pathway?

The CD28 dependent PI3K/Akt signaling pathway involves 15 genes. Key genes include: AKT3, FYN, LCK, MAPKAP1, MLST8, MTOR, PDPK1, PIK3CB, PIK3CD, PIK3CG.

CD28 dependent PI3K/Akt signaling

REACTOME PATHWAY

Reactome: R-HSA-38935715 genes45 compounds

The CD28 dependent PI3K/Akt signaling pathway (Reactome ID: R-HSA-389357) involves 15 genes and is affected by 45 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AKT3 FYN LCK MAPKAP1 MLST8 MTOR PDPK1 PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 RICTOR

Compounds Affecting CD28 dependent PI3K/Akt signaling

#	Compound	Targets Hit	Studies
1	Sirolimus	—	300
2	torin 1	—	10
3	pictilisib	—	25
4	ly294002	—	11
5	Wortmannin	—	300
6	Ku 0063794 [Supplementary Concept]	—	7
7	alpelisib	—	227
8	kenpaullone	—	8
9	Everolimus	—	297
10	egcg	—	300
11	Sorafenib	—	300
12	Crizotinib	—	298
13	Dasatinib	—	299
14	Acetic Acid Product of	—	300
15	sp600125	—	117
16	tyrphostin ag 1478	—	4
17	Quercetin	—	300
18	Rotenone	—	300
19	Thapsigargin	—	300
20	amn082	—	29
21	Calcimycin	—	216
22	Idarubicin	—	299
23	Idazoxan	—	300
24	Niclosamide	—	299
25	triolimus [Supplementary Concept]	—	33
26	tyrphostin 9	—	2
27	Ursolic Acid	—	300
28	Camptothecin	—	300
29	Dequalinium	—	136
30	Disulfiram	—	297
31	Emetine	—	298
32	Epinephrine	—	299
33	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
34	Maprotiline	—	299
35	Perphenazine	—	297
36	Afatinib	—	297
37	Axitinib	—	298
38	piceatannol	—	300
39	Swainsonine	—	300
40	Rosmarinic Acid	—	300
41	Genistein	—	300
42	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
43	Resveratrol	—	298
44	alsterpaullone	—	12
45	hydroxyfasudil [Supplementary Concept]	—	11

About the CD28 dependent PI3K/Akt signaling Pathway

The CD28 dependent PI3K/Akt signaling pathway is catalogued in Reactome (ID: R-HSA-389357) and involves 15 genes. In the BiohacksAI corpus, 45 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKT3, FYN, LCK, MAPKAP1, MLST8.