What compounds affect the Platelet homeostasis pathway?

110 compounds in the BiohacksAI corpus have documented interactions with genes in the Platelet homeostasis pathway (Reactome ID: R-HSA-418346). These compounds target 31 genes within this pathway.

What genes are in the Platelet homeostasis pathway?

The Platelet homeostasis pathway involves 31 genes. Key genes include: ATP2A1, ATP2A2, ATP2A3, FGR, GNAS, GUCY1A1, GUCY1A2, GUCY1B1, KCNMA1, KCNMB1.

Platelet homeostasis

REACTOME PATHWAY

Reactome: R-HSA-41834631 genes110 compounds

The Platelet homeostasis pathway (Reactome ID: R-HSA-418346) involves 31 genes and is affected by 110 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATP2A1 ATP2A2 ATP2A3 FGR GNAS GUCY1A1 GUCY1A2 GUCY1B1 KCNMA1 KCNMB1 KCNMB2 KCNMB4 MAPK14 NOS1 NOS2 NOS3 P2RX1 P2RX3 P2RX4 P2RX7 PAFAH2 PDE10A PDE1A PDE1B PDE2A PDE5A PPP2CA PPP2R5A PTGIR PTPN6+1 more

Compounds Affecting Platelet homeostasis

#	Compound	Targets Hit	Studies
1	Carvedilol	—	296
2	Promethazine	—	121
3	Thioridazine	—	35
4	Papaverine	—	299
5	pterostilbene	—	299
6	Fluocinolone Acetonide	—	295
7	Latanoprost	—	299
8	Nisoldipine	—	297
9	Amoxapine	—	259
10	nafadotride	—	14
11	3',4'-didemethylnobiletin [Supplementary Concept]	—	300
12	Nortriptyline	—	28
13	Perphenazine	—	297
14	Ritonavir	—	298
15	Adenosine Triphosphate	—	300
16	Budesonide	—	1,000
17	Resveratrol	—	298
18	Ethylestrenol	—	70
19	Ezetimibe	—	296
20	Thyroxine	—	994
21	Thyroxine	—	300
22	Sorafenib	—	300
23	Nitroarginine	—	300
24	Arginine	—	300
25	Arginine	—	300
26	NG-Nitroarginine Methyl Ester	—	238
27	Benzydamine	—	298
28	Glyburide	—	298
29	Irbesartan	—	298
30	Simvastatin	—	1,000
31	Oxcarbazepine	—	296
32	Ursodeoxycholic Acid	—	298
33	Lovastatin	—	300
34	Nicardipine	—	94
35	Hexachlorophene	—	300
36	Dasatinib	—	299
37	tyrphostin ag 1478	—	4
38	Guanethidine	—	300
39	Suramin	—	300
40	vinpocetine	—	299
41	Okadaic Acid	—	300
42	paxilline	—	42
43	Oxaprozin	—	181
44	Calcitriol	—	300
45	Chlorpheniramine	—	157
46	Desoximetasone	—	86
47	Disulfiram	—	297
48	Etodolac	—	296
49	Levonorgestrel	—	292
50	Norgestrel	—	300

About the Platelet homeostasis Pathway

The Platelet homeostasis pathway is catalogued in Reactome (ID: R-HSA-418346) and involves 31 genes. In the BiohacksAI corpus, 110 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATP2A1, ATP2A2, ATP2A3, FGR, GNAS.