What compounds affect the Signaling by Retinoic Acid pathway?

190 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by Retinoic Acid pathway (Reactome ID: R-HSA-5362517). These compounds target 12 genes within this pathway.

What genes are in the Signaling by Retinoic Acid pathway?

The Signaling by Retinoic Acid pathway involves 12 genes. Key genes include: AKR1C3, ALDH1A1, DLD, FABP5, PDK1, PPARD, RARA, RARB, RARG, RXRA.

Signaling by Retinoic Acid

REACTOME PATHWAY

Reactome: R-HSA-536251712 genes190 compounds

The Signaling by Retinoic Acid pathway (Reactome ID: R-HSA-5362517) involves 12 genes and is affected by 190 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AKR1C3 ALDH1A1 DLD FABP5 PDK1 PPARD RARA RARB RARG RXRA RXRB RXRG

Compounds Affecting Signaling by Retinoic Acid

#	Compound	Targets Hit	Studies
1	Calcitriol	—	300
2	Progesterone	—	299
3	Gemfibrozil	—	297
4	Linoleic Acid	—	300
5	Disulfiram	—	297
6	Adapalene	—	296
7	Dactinomycin	—	297
8	Ethidium	—	300
9	Genistein	—	300
10	Rotenone	—	300
11	Retinaldehyde	—	300
12	methyl 13-(alpha-naphthalene)aminodeisopropyldehydroabietate [Supplementary Concept]	—	161
13	Thyroxine	—	994
14	Thyroxine	—	300
15	Arachidonic Acid	—	245
16	cycloheximide	—	300
17	Hexachlorophene	—	300
18	Astemizole Antihistamine drug now withdrawn from	—	280
19	Promethazine	—	121
20	Vitamin	—	295
21	Chlorhexidine	—	299
22	Clotrimazole	—	296
23	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
24	Testosterone	—	299
25	Aprepitant	—	297
26	Dasatinib	—	299
27	Daunorubicin	—	298
28	Fluspirilene	—	74
29	Flutamide	—	298
30	Idazoxan	—	300
31	Medroxyprogesterone Acetate	—	299
32	Niclosamide	—	299
33	Spironolactone	—	298
34	Triiodothyronine	—	300
35	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
36	chrysin	—	300
37	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	1,000
38	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	293
39	Bortezomib	—	300
40	Dihydrotestosterone	—	300
41	Ethinyl Estradiol	—	300
42	Loratadine	—	296
43	Vitamin K 3	—	300
44	Perphenazine	—	297
45	Piperazine	—	299
46	Sulfanilamide	—	300
47	Oxaprozin	—	181
48	Oleic Acid	—	112
49	Mepentol [Supplementary Concept]	—	184
50	Palmitic Acid	—	300

About the Signaling by Retinoic Acid Pathway

The Signaling by Retinoic Acid pathway is catalogued in Reactome (ID: R-HSA-5362517) and involves 12 genes. In the BiohacksAI corpus, 190 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKR1C3, ALDH1A1, DLD, FABP5, PDK1.