What compounds affect the Dectin-2 family pathway?

206 compounds in the BiohacksAI corpus have documented interactions with genes in the Dectin-2 family pathway (Reactome ID: R-HSA-5621480). These compounds target 4 genes within this pathway.

What genes are in the Dectin-2 family pathway?

The Dectin-2 family pathway involves 4 genes. Key genes include: FYN, LYN, MUC1, SYK.

Dectin-2 family

REACTOME PATHWAY

Reactome: R-HSA-56214804 genes206 compounds

The Dectin-2 family pathway (Reactome ID: R-HSA-5621480) involves 4 genes and is affected by 206 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

FYN LYN MUC1 SYK

Compounds Affecting Dectin-2 family

#	Compound	Targets Hit	Studies
1	Dasatinib	—	299
2	Crizotinib	—	298
3	tyrphostin ag 1478	—	4
4	Sorafenib	—	300
5	kenpaullone	—	8
6	sp600125	—	117
7	alsterpaullone	—	12
8	Ouabain	—	300
9	Atorvastatin	—	1,000
10	Simvastatin	—	1,000
11	Methotrexate	—	289
12	Chlorhexidine	—	299
13	Clofarabine	—	298
14	Colchicine	—	300
15	cycloheximide	—	300
16	deguelin [Supplementary Concept]	—	151
17	Digoxin	—	299
18	Disulfiram	—	297
19	Emetine	—	298
20	Ezetimibe	—	296
21	Lovastatin	—	300
22	Medroxyprogesterone Acetate	—	299
23	Melphalan	—	300
24	Mometasone Furoate	—	292
25	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
26	Niclosamide	—	299
27	piceatannol	—	300
28	Podophyllotoxin	—	14
29	Thapsigargin	—	300
30	torin 1	—	10
31	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
32	Trifluridine	—	295
33	fisetin	—	78
34	ag490	—	14
35	alpelisib	—	227
36	Axitinib	—	298
37	Azathioprine	—	300
38	Bortezomib	—	300
39	Maprotiline	—	299
40	Nocodazole Nocodazole is	—	215
41	N-pyridazin-3-yl-4-(3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzylidene)piperidine-1-carboxamide [Supplementary Concept]	—	8
42	Tripterygium	—	300
43	Vincristine	—	299
44	withaferin	—	300
45	Berberine	—	300
46	cbd	—	298
47	Doxycycline	—	999
48	Methylene Blue	—	200
49	Minocycline	—	297
50	Sertraline	—	1,000

About the Dectin-2 family Pathway

The Dectin-2 family pathway is catalogued in Reactome (ID: R-HSA-5621480) and involves 4 genes. In the BiohacksAI corpus, 206 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include FYN, LYN, MUC1, SYK.